1.13.11.79: aerobic 5,6-dimethylbenzimidazole synthase
This is an abbreviated version!
For detailed information about aerobic 5,6-dimethylbenzimidazole synthase, go to the full flat file.
Reaction
Synonyms
BluB, bluB/cobT2, DMB-synthase, EC 1.14.99.40, flavin destructase, flavin destructase enzyme
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 1.13.11.79 - aerobic 5,6-dimethylbenzimidazole synthase
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REACTION DIAGRAM
FMNH2 + NADH + H+ + O2
5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD+ + ?
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5,6-dimethylbenzimidazole is the lower axial ligand of vitamin B12, i.e. cobalamin
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?
FMNH2 + NADH + H+ + O2 + alloxan
5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD+ + dialuric acid
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?
FMNH2 + O2
5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialiric acid + pyrimidinetrione + alloxan
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the rate of formation of the intermediate product unprotonated C4a-peroxyflavin is influenced by substitutions at C8 of FMN
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?
5,6-dimethylbenzimidazole + ?
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FMNH2 reacts with oxygen to yield flavin hydroperoxide, which then undergoes a ring expansion with loss of a water molecule to produce intermediate A. This disintegrates further as a result of four hydrolysis reactions in which it is attacked by water molecules. The resulting diaminobenzene product undergoes two oxidation reactions, to form 5,6-dimethylbenzimidazole
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?
5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + urea + ?
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?
FMNH2 + O2
5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + urea + ?
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?