1.13.11.79: aerobic 5,6-dimethylbenzimidazole synthase
This is an abbreviated version!
For detailed information about aerobic 5,6-dimethylbenzimidazole synthase, go to the full flat file.
Reaction
Synonyms
BluB, bluB/cobT2, DMB-synthase, EC 1.14.99.40, flavin destructase, flavin destructase enzyme
ECTree
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Reference on EC 1.13.11.79 - aerobic 5,6-dimethylbenzimidazole synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gray, M.J.; Escalante-Semerena, J.C.
Single-enzyme conversion of FMNH2 to 5,6-dimethylbenzimidazole, the lower ligand of B12
Proc. Natl. Acad. Sci. USA
104
2921-2926
2007
Rhodospirillum rubrum (Q2RNG5)
Taga, M.; Larsen, N.; Howard-Jones, A.; Walsh, C.; Walker, G.
BluB cannibalizes flavin to form the lower ligand of vitamin B12
Nature
446
449-453
2007
Sinorhizobium meliloti
Campbell, G.; Taga, M.; Mistry, K.; Lloret, J.; Anderson, P.; Roth, J.; Walker, G.
Sinorhizobium meliloti bluB is necessary for production of 5,6-dimethylbenzimidazole, the lower ligand of B12
Proc. Natl. Acad. Sci. USA
103
4634-4639
2006
Sinorhizobium meliloti
Wang, X.L.; Quan, J.M.
Intermediate-assisted multifunctional catalysis in the conversion of flavin to 5,6-dimethylbenzimidazole by BluB: a density functional theory study
J. Am. Chem. Soc.
133
4079-4091
2011
Sinorhizobium meliloti
Collins, H.F.; Biedendieck, R.; Leech, H.K.; Gray, M.; Escalante-Semerena, J.C.; McLean, K.J.; Munro, A.W.; Rigby, S.E.; Warren, M.J.; Lawrence, A.D.
Bacillus megaterium has both a functional BluB protein required for DMB synthesis and a related flavoprotein that forms a stable radical species
PLoS ONE
8
e55708
2013
Priestia megaterium, Rhodobacter capsulatus
Yu, T.Y.; Mok, K.C.; Kennedy, K.J.; Valton, J.; Anderson, K.S.; Walker, G.C.; Taga, M.E.
Active site residues critical for flavin binding and 5,6-dimethylbenzimidazole biosynthesis in the flavin destructase enzyme BluB
Protein Sci.
21
839-849
2012
Sinorhizobium meliloti (Q92PC8), Sinorhizobium meliloti
Ealick, S.; Begley, T.
Biochemistry: Molecular cannibalism
Nature
446
387-389
2007
Sinorhizobium meliloti
Deptula, P.; Kylli, P.; Chamlagain, B.; Holm, L.; Kostiainen, R.; Piironen, V.; Savijoki, K.; Varmanen, P.
BluB/CobT2 fusion enzyme activity reveals mechanisms responsible for production of active form of vitamin B12 by Propionibacterium freudenreichii
Microb. Cell Fact.
14
186
2015
Propionibacterium freudenreichii subsp. shermanii (D7GJ95), Propionibacterium freudenreichii subsp. shermanii DSM 4902 (D7GJ95)
Hazra, A.; Ballou, D.; Taga, M.
Unique biochemical and sequence features enable BluB to destroy flavin and distinguish BluB from the flavin monooxygenase superfamily
Biochemistry
57
1748-1757
2018
Sinorhizobium meliloti
Walworth, N.; Lee, M.; Suffridge, C.; Qu, P.; Fu, F.; Saito, M.; Webb, E.; Sanudo-Wilhelmy, S.; Hutchins, D.
Functional genomics and phylogenetic evidence suggest genus-wide cobalamin production by the globally distributed marine nitrogen fixer Trichodesmium
Front. Microbiol.
9
189
2018
Trichodesmium sp.
