1.13.11.79: aerobic 5,6-dimethylbenzimidazole synthase

This is an abbreviated version!
For detailed information about aerobic 5,6-dimethylbenzimidazole synthase, go to the full flat file.

Reaction

Synonyms

BluB, bluB/cobT2, DMB-synthase, EC 1.14.99.40, flavin destructase, flavin destructase enzyme

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.11 With incorporation of two atoms of oxygen

                1.13.11.79 aerobic 5,6-dimethylbenzimidazole synthase

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Results

in table

2849

AA Sequence

5

Cloned(Commentary)

2

Cofactor

8

General Information

1

Inhibitors

1

Ki Value [mM]

4

KM Value [mM]

4

Molecular Weight [Da]

7

Natural Substrates/ Products (Substrates)

12

Organism

5

Pathway

1

pH Optimum

19

Protein Variants

3

Purification (Commentary)

2

Reaction

12

Reference

14

Substrates and Products (Substrate)

3

Subunits

20

Synonyms

1

Systematic Name

3

Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.13.11.79 - aerobic 5,6-dimethylbenzimidazole synthase

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SYSTEMATIC NAME

IUBMB Comments

FMNH2 oxidoreductase (5,6-dimethylbenzimidazole forming)

The enzyme catalyses a complex oxygen-dependent conversion of reduced flavin mononucleotide to form 5,6-dimethylbenzimidazole, the lower ligand of vitamin B12. This conversion involves many sequential steps in two distinct stages, and an alloxan intermediate that acts as a proton donor, a proton acceptor, and a hydride acceptor [4]. The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the ribityl group of FMNH2 and 2-H from the ribityl 1'-pro-S hydrogen. While D-erythrose 4-phosphate has been shown to be one of the byproducts, the nature of the other product(s) has not been verified yet.