1.13.11.79: aerobic 5,6-dimethylbenzimidazole synthase

This is an abbreviated version!
For detailed information about aerobic 5,6-dimethylbenzimidazole synthase, go to the full flat file.

Reaction

Synonyms

BluB, bluB/cobT2, DMB-synthase, EC 1.14.99.40, flavin destructase, flavin destructase enzyme

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.11 With incorporation of two atoms of oxygen

1.13.11.79 aerobic 5,6-dimethylbenzimidazole synthase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
2849	AA Sequence
5	Cloned(Commentary)
2	Cofactor
8	General Information
1	Inhibitors
1	Ki Value [mM]
4	KM Value [mM]
4	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
12	Organism
5	Pathway
1	pH Optimum
19	Protein Variants
3	Purification (Commentary)
2	Reaction
12	Reference
14	Substrates and Products (Substrate)
3	Subunits
20	Synonyms
1	Systematic Name
3	Turnover Number [1/s]

Systematic Name

print visible entries

print all entries

Systematic Name on EC 1.13.11.79 - aerobic 5,6-dimethylbenzimidazole synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Systematic Name Search

FMNH2 oxidoreductase (5,6-dimethylbenzimidazole forming)

The enzyme catalyses a complex oxygen-dependent conversion of reduced flavin mononucleotide to form 5,6-dimethylbenzimidazole, the lower ligand of vitamin B12. This conversion involves many sequential steps in two distinct stages, and an alloxan intermediate that acts as a proton donor, a proton acceptor, and a hydride acceptor [4]. The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the ribityl group of FMNH2 and 2-H from the ribityl 1'-pro-S hydrogen. While D-erythrose 4-phosphate has been shown to be one of the byproducts, the nature of the other product(s) has not been verified yet.