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BRENDA support aerobic 5,6-dimethylbenzimidazole synthase

This is an abbreviated version!
For detailed information about aerobic 5,6-dimethylbenzimidazole synthase, go to the full flat file.


D-erythrose 4-phosphate
other product(s)


BluB, bluB/cobT2, DMB-synthase, EC, flavin destructase, flavin destructase enzyme


     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
       aerobic 5,6-dimethylbenzimidazole synthase

Systematic Name

Systematic Name on EC - aerobic 5,6-dimethylbenzimidazole synthase

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IUBMB Comments
FMNH2 oxidoreductase (5,6-dimethylbenzimidazole forming)
The enzyme catalyses a complex oxygen-dependent conversion of reduced flavin mononucleotide to form 5,6-dimethylbenzimidazole, the lower ligand of vitamin B12. This conversion involves many sequential steps in two distinct stages, and an alloxan intermediate that acts as a proton donor, a proton acceptor, and a hydride acceptor [4]. The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the ribityl group of FMNH2 and 2-H from the ribityl 1'-pro-S hydrogen. While D-erythrose 4-phosphate has been shown to be one of the byproducts, the nature of the other product(s) has not been verified yet.