184.108.40.206: aerobic 5,6-dimethylbenzimidazole synthase
This is an abbreviated version!
For detailed information about aerobic 5,6-dimethylbenzimidazole synthase, go to the full flat file.
BluB, bluB/cobT2, DMB-synthase, EC 220.127.116.11, flavin destructase, flavin destructase enzyme
Advanced search results
Systematic Name on EC 18.104.22.168 - aerobic 5,6-dimethylbenzimidazole synthase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
FMNH2 oxidoreductase (5,6-dimethylbenzimidazole forming)
The enzyme catalyses a complex oxygen-dependent conversion of reduced flavin mononucleotide to form 5,6-dimethylbenzimidazole, the lower ligand of vitamin B12. This conversion involves many sequential steps in two distinct stages, and an alloxan intermediate that acts as a proton donor, a proton acceptor, and a hydride acceptor . The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the ribityl group of FMNH2 and 2-H from the ribityl 1'-pro-S hydrogen. While D-erythrose 4-phosphate has been shown to be one of the byproducts, the nature of the other product(s) has not been verified yet.