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1.13.11.85: exo-cleaving rubber dioxygenase

This is an abbreviated version!
For detailed information about exo-cleaving rubber dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.85

Reaction

cis-1,4-polyisoprene
+ n O2 = n (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal

Synonyms

heme-dependent rubber oxygenase, LATA, poly(cis-1,4-isoprene)-cleavage enzyme, roxA, RoxB, RubA, rubber oxygenase, rubber oxygenase A

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.85 exo-cleaving rubber dioxygenase

Inhibitors

Inhibitors on EC 1.13.11.85 - exo-cleaving rubber dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-S-octyl-beta-D-thioglucopyranoside
0.5%, complete inhibition
2,2'-dipyridyl
10 mM, 85% inhibition
2-mercaptoethanol
5 mM, 2% residual activity; 5 mM, complete inhibition
3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate
0.5%, complete inhibition
alpha,alpha-bipyridyl
10 mM, 15% residual activity
carbon monoxide
-
CO
carbon monoxide strongly inhibits the polyisoprene cleavage reaction of RoxAXsp
Dithionite
reduction of RoxA results in a reversible inactivation of the enzyme
dithiothreitol
5 mM, 6% residual activity; 5 mM, 94% inhibition
imidazole
presence results in a reversible inactivation of the enzyme
N-ethylmaleimide
10 mM, 31% residual activity; 10 mM, 69% inhibition
NADH
reduction of RoxA results in a reversible inactivation of the enzyme
octyl beta-glucoside
0.5% mM, 2% residual activity
octyl-beta-glucoside
0.5%, complete inhibition
p-chloromercuribenzoate
10 mM, 24% inhibition
Plysurf A210G
0.5%, complete inhibition
-
SDS
0.5%, 2% residual activity; 0.5%, complete inhibition
sodium cholate
0.5%, 68% inhibition
Tiron
10 mM, 27% inhibition
Triton X-100
0.5%, complete inhibition
Tween 80
0.5%, complete inhibition; 0.5% mM, 2% residual activity