1.13.11.9: 2,5-dihydroxypyridine 5,6-dioxygenase

This is an abbreviated version!
For detailed information about 2,5-dihydroxypyridine 5,6-dioxygenase, go to the full flat file.

Reaction

Synonyms

2,5-DHP dioxygenase, 2,5-dihydroxypyridine dioxygenase, 2,5-dihydroxypyridine oxygenase, 2,5DHP dioxygenase, EC 1.13.1.9, NicX, NicX protein, oxygenase, 2,5-dihydroxypyridine 5,6-di-, pyridine-2,5-diol dioxygenase

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.11 With incorporation of two atoms of oxygen

                1.13.11.9 2,5-dihydroxypyridine 5,6-dioxygenase

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Results	in table
3	Activating Compound
278	AA Sequence
2	Application
1	CAS Registry Number
4	Cloned(Commentary)
1	Cofactor
4	Crystallization (Commentary)
3	General Information
7	General Stability
24	Inhibitors
2	KM Value [mM]
2	Localization
10	Metals/Ions
7	Molecular Weight [Da]
16	Natural Substrates/ Products (Substrates)
136	Organism
1	Oxidation Stability
7	Pathway
18	PDB ID
5	pH Optimum
2	Protein Variants
5	Purification (Commentary)
1	Reaction
3	Reaction Type
14	Reference
2	Source Tissue
5	Specific Activity [micromol/min/mg]
5	Storage Stability
28	Substrates and Products (Substrate)
8	Subunits
23	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Stability [°C]

General Stability

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General Stability on EC 1.13.11.9 - 2,5-dihydroxypyridine 5,6-dioxygenase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

combination of dithiothreitol and FeSO4 is detrimental during long-term incubation at 0°C

Pseudomonas putida

-

396333, 396334

dialysis against phosphate buffer: complete loss of activity

Achromobacter sp.

-

396336

dithiothreitol stabilizes

Pseudomonas putida

-

396333, 396334

incubation with or dialysis against 0.001 mM 8-hydroxyquinoline and by (NH4)2SO4 fractionation: complete loss of activity

Achromobacter sp.

-

396336

L-cysteine: enzyme has a specific requirement for L-cysteine, 6.7 mM, required to restore full activity after dialysis or treatment with chelating agents

Achromobacter sp.

-

396336