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1.13.11.92: fatty acid alpha-dioxygenase

This is an abbreviated version!
For detailed information about fatty acid alpha-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.92

Reaction

a fatty acid
+
O2
=
a (2R)-2-hydroperoxyfatty acid

Synonyms

alpha-dioxygenase, alpha-DOX1, AXX17_At3g00510, cce_4307, DOX1, fatty acid alpha-oxidase, PADOX-1, Piox

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.92 fatty acid alpha-dioxygenase

Systematic Name

Systematic Name on EC 1.13.11.92 - fatty acid alpha-dioxygenase

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SYSTEMATIC NAME
IUBMB Comments
fatty acid:oxygen 2-oxidoreductase [(2R)-2-hydroperoxyfatty acid-forming]
Contains heme. This plant enzyme catalyses the (2R)-hydroperoxidation of fatty acids. It differs from lipoxygenases and cyclooxygenases in that the oxygen addition does not target an unsaturated region in the fatty acid. In vitro the product undergoes spontaneous decarboxylation, resulting in formation of a chain-shortened aldehyde. In vivo the product may be reduced to a (2R)-2-hydroxyfatty acid. The enzyme, which is involved in responses to different abiotic and biotic stresses, has a wide substrate range that includes both saturated and unsaturated fatty acids.