1.13.12.16: nitronate monooxygenase

This is an abbreviated version!
For detailed information about nitronate monooxygenase, go to the full flat file.

Word Map on EC 1.13.12.16

Reaction

ethylnitronate
+
O2
=
acetaldehyde
+
nitrite
+
other products

Synonyms

2-nitropropane dioxygenase, NAO, nitroalkane oxidase, nitroalkane-oxidizing enzyme, nitronate monooxygenase, nitropropane dioxygenase, NMO, NMO-Nc, NMO-Ws, nmoA, oxidase, nitroalkane, oxygenase, 2-nitropropane di-, P3N monooxygenase, Pa-NMO, PA4202, protein PA4202, Rv1894c, Sa-NAO

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
                1.13.12.16 nitronate monooxygenase

Inhibitors

Inhibitors on EC 1.13.12.16 - nitronate monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
3-(3,4-dihydroxyphenyl)-L-Ala
-
-
3-nitro-1-propionate
-
competitive inhibitor, pH 7.0, 30°C
4-hydroxy-2,2,6,6-tetramethyl-piperidinooxy radical
-
-
5-hydroxytryptophan
-
-
8-hydroxyquinoline
-
strong inhibition
acetone
-
inhibits competitively against 2-nitropropane, no inhibitory effect against O2
alpha-Naphthol
-
-
cysteine
-
marked decrease in enzyme activity
cytochrome c
dithiothreitol
EDTA
-
1 mM, relative activity remaining 95%
epinephrine
ethylnitronate
-
-
HgCl2
hydroquinone
-
-
iodoacetate
-
1 mM, complete inhibition
KCN
-
strongly
m-Nitrobenzoate
-
-
N-ethylmaleimide
NADPH
-
competitive inhibitor. oxygenation is inhibited approximately 100% by 0.1 mM NADPH, respectively, although NAD+ and NADP+ are ineffective even at 1 mM. During the inhibition, NADH and NADPH are oxidized
nitrite
-
inhibits noncompetitively against 2-nitropropane, functioned as a noncompetitive inhibitor against oxygen in the presence of excess 2-nitropropane (50 mM)
Nitro blue tetrazolium
Nitromethane
-
inhibits noncompetitively
p-chloromercuribenzoate
phloroglucinol
-
-
pyrogallol
-
-
resorcinol
-
-
Superoxide dismutase
-
Thiophenol
-
-
Tiron
additional information
-