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1.13.12.17: dichloroarcyriaflavin A synthase

This is an abbreviated version!
For detailed information about dichloroarcyriaflavin A synthase, go to the full flat file.

Reaction

dichlorochromopyrrolate
+ 4 O2 + 4 NADH + 4 H+ =
dichloroarcyriaflavin A
+ 2 CO2 + 6 H2O + 4 NAD+

Synonyms

CYP245A1, cytochrome P450 StaP, P450 StaP, StaP

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
                1.13.12.17 dichloroarcyriaflavin A synthase

Crystallization

Crystallization on EC 1.13.12.17 - dichloroarcyriaflavin A synthase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
X-ray crystal structures of chromopyrrolic acid-bound and chromopyrrolic acid-free forms of enzyme component StaP. The enzyme attains a more ordered conformation upon binding of the substrate. Substantial conformational changes are observed at and around the substrate-binding pocket to optimize interactions with the enzyme. The enzyme–chromopyrrolic acid complex structure reveals that chromopyrrolic acid has a twisted-butterfly shape in the active site, which is perpendicular to the heme plane