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BRENDA support dichloroarcyriaflavin A synthase

This is an abbreviated version!
For detailed information about dichloroarcyriaflavin A synthase, go to the full flat file.


+ 4 O2 + 4 NADH + 4 H+ =
dichloroarcyriaflavin A
+ 2 CO2 + 6 H2O + 4 NAD+


CYP245A1, cytochrome P450 StaP, P450 StaP, StaP


     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
       dichloroarcyriaflavin A synthase

Systematic Name

Systematic Name on EC - dichloroarcyriaflavin A synthase

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IUBMB Comments
dichlorochromopyrrolate,NADH:oxygen 2,5-oxidoreductase (dichloroarcyriaflavin A-forming)
The conversion of dichlorochromopyrrolate to dichloroarcyriaflavin A is a complex process that involves two enzyme components. RebP is an NAD-dependent cytochrome P-450 oxygenase that performs an aryl-aryl bond formation yielding the six-ring indolocarbazole scaffold [1]. Along with RebC, a flavin-dependent hydroxylase, it also catalyses the oxidative decarboxylation of both carboxyl groups. The presence of RebC ensures that the only product is the rebeccamycin aglycone dichloroarcyriaflavin A [2]. The enzymes are similar, but not identical, to StaP and StaC, which are involved in the synthesis of staurosporine [3].