1.13.12.2: lysine 2-monooxygenase
This is an abbreviated version!
For detailed information about lysine 2-monooxygenase, go to the full flat file.
Word Map on EC 1.13.12.2
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1.13.12.2
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putida
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5-aminovalerate
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glutarate
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fed-batch
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nylon
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synthesis
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fluorescens
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semialdehyde
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1,5-pentanediol
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polyamides
-
glutamicum
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flavoproteins
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corynebacterium
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l-pipecolate
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biotechnology
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4-aminobutyrate
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five-carbon
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amidohydrolase
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his6-tagged
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cadaverine
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biomass
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transaminase
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permease
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byproduct
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deamination
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putrescine
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bio-based
-
feedstock
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codon-optimized
- 1.13.12.2
- putida
- 5-aminovalerate
- glutarate
-
fed-batch
-
nylon
- synthesis
- fluorescens
- semialdehyde
- 1,5-pentanediol
- polyamides
- glutamicum
- flavoproteins
-
corynebacterium
- l-pipecolate
- biotechnology
- 4-aminobutyrate
-
five-carbon
-
amidohydrolase
-
his6-tagged
- cadaverine
- biomass
- transaminase
-
permease
-
byproduct
-
deamination
- putrescine
-
bio-based
-
feedstock
-
codon-optimized
Reaction
Synonyms
davB, L-AAO/MOG, L-amino acid oxidase/monooxygenase, L-LOX/MOG, L-lysine 2-monooxygenase, L-lysine monooxygenase, L-lysine oxidase/monooxygenase, L-lysine-2-monooxygenase, lysine monooxygenase, lysine oxygenase
ECTree
1.13.12.2 lysine 2-monooxygenaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.13.12.2 - lysine 2-monooxygenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-methyllysine + O2
2-keto-4-methyl-6-amino-n-hexanoate + NH3 + H2O2
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oxidase activity
-
?
5-methyllysine + O2
4-methyl-5-aminopentanamide + CO2 + H2O
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monooxygenase activity
-
?
alanine + propylamine + O2
?
-
monooxygenase and oxidase activity
-
-
?
alanine + propylamine + phenazine methosulfate
pyruvate + NH3 + reduced phenazine methosulfate
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anaerobic conditions, ferricyanide as terminal electron acceptor, dehydrogenase activity
-
?
DL-2,8-diaminooctanoate + O2
2-keto-8-aminooctanoate + NH3 + H2O2
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oxidase activity
-
-
?
DL-7,8-diaminoheptanoate + O2
6-aminohexanamide + CO2 + H2O
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monooxygenase activity
-
-
?
L-arginine + O2
2-amino-5-guanidinovalerate + NH3 + H2O2
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oxidase activity
-
-
?
L-arginine + O2
4-guanidinobutanamide + CO2 + H2O
-
-
-
?
L-arginine + phenazine methosulfate
2-keto-5-guanidinovalerate + NH3 + reduced phenazine methosulfate
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anaerobic conditions, ferricyanide as terminal electron acceptor, dehydrogenase activity
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?
L-lysine + electron acceptor
?
-
anaerobic conditions, electron acceptors are methylene blue, toluylene blue, phenol blue or thymol indophenol
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
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enzymes with dual activities in a single active site: L-lysine oxidase and L-lysine monooxygenase
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-
?
L-lysine + phenazine methosulfate
2-keto-6-amino-n-hexanoate + NH3 + reduced phenazine methosulfate
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anaerobic conditions, ferricyanide as terminal electron acceptor, dehydrogenase activity
-
?
L-ornithine + O2
2-keto-5-amino-n-pentanoate + NH3 + H2O2
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oxidase activity
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoate + NH3 + H2O2
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enzymes with dual activities in a single active site: L-lysine oxidase and L-lysine monooxygenase
-
-
?
L-ornithine + phenazine methosulfate
2-keto-5-aminopentanoate + NH3 + reduced phenazine methosulfate
-
anaerobic conditions, ferricyanide as terminal electron acceptor, dehydrogenase activity
-
?
Nepsilon-methyllysine + O2
5-methylaminopentanamide + CO2 + H2O
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monooxygenase activity
-
?
L-arginine + O2
4-guanidinobutyramide + CO2 + H2O
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monooxygenase activity
-
-
?
L-arginine + O2
4-guanidinobutyramide + CO2 + H2O
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monooxygenase activity
-
?
L-arginine + O2
4-guanidinobutyramide + CO2 + H2O
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monooxygenase activity
-
-
?
L-lysine + O2
2-keto-6-amino-n-hexanoate + NH3 + H2O2
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oxidase activity
-
?
L-lysine + O2
2-keto-6-amino-n-hexanoate + NH3 + H2O2
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oxidase activity
-
-
?
L-lysine + O2
5-aminopentanamide + CO2 + H2O
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monooxygenase activity
-
?
L-lysine + O2
5-aminopentanamide + CO2 + H2O
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monooxygenase activity
-
-
?
L-lysine + O2
5-aminopentanamide + CO2 + H2O
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monooxygenase activity
-
?
L-lysine + O2
5-aminopentanamide + CO2 + H2O
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monooxygenase activity
-
-
?
L-lysine + O2
5-aminopentanamide + CO2 + H2O
-
monooxygenase activity
-
?
L-lysine + O2
5-aminopentanamide + CO2 + H2O
-
-
-
-
?
L-lysine + O2
5-aminopentanamide + CO2 + H2O
-
-
-
?
L-lysine + O2
5-aminopentanamide + CO2 + H2O
the mechanistic features are reported that are important for allowing the single active site of L-LOX/MOG to catalyze the two reactions of apparent monooxygenation and the oxidation of the flavoprotein oxidase
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-
?
L-lysine + O2
5-aminopentanamide + CO2 + H2O
preferred substrate
-
-
?
L-lysine + O2
5-aminopentanamide + CO2 + H2O
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enzymes with dual activities in a single active site: L-lysine oxidase and L-lysine monooxygenase
-
-
?
L-ornithine + O2
4-aminobutanamide + CO2 + H2O
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enzymes with dual activities in a single active site: L-lysine oxidase and L-lysine monooxygenase
-
-
?
additional information
?
-
-
analogs with a modified carboxyl or alpha-amino group are inactive as substrates
-
-
?
additional information
?
-
-
monooxygenase, oxidase and dehydrogenase reaction catalyzed by a single enzyme molecule
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-
?
additional information
?
-
-
monooxygenase, oxidase and dehydrogenase reaction catalyzed by a single enzyme molecule
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-
?
additional information
?
-
-
enzyme specific for O2 as electron acceptor, no dehydrogenase activity
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-
?
additional information
?
-
-
alkylamine dependent oxygenation of alpha-monoamino acids
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-
?
additional information
?
-
-
alkylamine dependent oxygenation of alpha-monoamino acids
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-
?
additional information
?
-
-
L-lysine analogs with a chloro or hydroxyl group at either the delta or the gamma position are both oxygenated and oxidized
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-
?
additional information
?
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bifunctional L-amino acid oxidase, EC 1.4.3.2, of Pseudomonas sp. AIU813, renamed as L-amino acid oxidase/monooxygenase (L-AAO/MOG), exhibits L-lysine 2-monooxygenase as well as oxidase activity
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-
?
