1.13.12.3: tryptophan 2-monooxygenase

This is an abbreviated version, for detailed information about tryptophan 2-monooxygenase, go to the full flat file.

Reaction

L-tryptophan
+
O2
=
(indol-3-yl)acetamide
+
CO2
+
H2O

Synonyms

IaaM, oxygenase, tryptophan 2-mono-, Pgt-IaaM, PGTG_11658, TMO, tryptophan 2-monooxygenase, tryptophan monooxygenase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
                1.13.12.3 tryptophan 2-monooxygenase

Inhibitors

Inhibitors on EC 1.13.12.3 - tryptophan 2-monooxygenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
weak
2-methyl methanethiolsulfonate
-
-
2-Oxo-3-pentynoate
-
-
3-Indoleacetamide
-
-
3-indolepyruvate
-
-
CaCl2
-
little or no effect
D-methionine
-
competitive inhibition
D-phenylalanine
-
competitive inhibition
D-tryptophan
Diethylpyrocarbonate
-
-
diethylthiocarbonate
-
-
EDTA
-
little or no effect
Hydrocinnamic acid
-
competitive inhibition
hydroxylamine
-
-
Indole-3-acetaldehyde
-
weak
Indole-3-acetamide
indole-3-acetic acid
-
-
Indole-3-pyruvate
-
-
iodoacetamide
-
-
K3Fe(CN)6
-
weak
KCN
-
little or no effect
L-glutathione
-
reduced
N-ethylmaleimide
-
-
phenylacetamide
-
competitive inhibition
Phenylethylamine
-
competitive inhibition
phenyllactic acid
-
competitive inhibition
phenylpyruvic acid
-
competitive inhibition
Quinacrine
-
weak
Semicarbazide
-
-
tryptamine
-
competitive inhibition
Vinylglycine
-
-