1.13.12.3: tryptophan 2-monooxygenase

This is an abbreviated version!
For detailed information about tryptophan 2-monooxygenase, go to the full flat file.

Word Map on EC 1.13.12.3

Reaction

L-tryptophan
+
O2
=
(indol-3-yl)acetamide
+
CO2
+
H2O

Synonyms

IaaM, oxygenase, tryptophan 2-mono-, Pgt-IaaM, PGTG_11658, TMO, tryptophan 2-monooxygenase, tryptophan monooxygenase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
                1.13.12.3 tryptophan 2-monooxygenase

Reference

Reference on EC 1.13.12.3 - tryptophan 2-monooxygenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kosuge, T.; Heskett, M.G.; Wilson, E.E.
Microbial synthesis and degradation of indole-3-acetic acid. I. The conversion of L-tryptophan to indole-3-acetamide by an enzyme system from Pseudomonas savastanoi
J. Biol. Chem.
241
3738-3744
1966
Pseudomonas savastanoi
Manually annotated by BRENDA team
Comai, L.; Kosuge, T.
Involvement of plasmid deoxyribonucleic acid in indoleacetic acid synthesis in Pseudomonas savastanoi
J. Bacteriol.
143
950-957
1980
Pseudomonas savastanoi
Manually annotated by BRENDA team
Hutcheson, S.W.; Kosuge, T.
Regulation of 3-indoleacetic acid production in Pseudomonas syringae pv. savastanoi. Purification and properties of tryptophan 2-monooxygenase
J. Biol. Chem.
260
6281-6287
1985
Pseudomonas savastanoi
Manually annotated by BRENDA team
Yamada, T.; Palm, C.J.; Brooks, B.; Kosuge, T.
Nucleotide sequences of the Pseudomonas savastanoi indoleacetic acid genes show homology with Agrobacterium tumefaciens T-DNA
Proc. Natl. Acad. Sci. USA
82
6522-6526
1985
Agrobacterium tumefaciens, Pseudomonas savastanoi
Manually annotated by BRENDA team
Comai, L.; Kosuge, T.
Cloning characterization of iaaM, a virulence determinant of Pseudomonas savastanoi
J. Bacteriol.
149
40-46
1982
Pseudomonas savastanoi
Manually annotated by BRENDA team
Sobrado, P.; Fitzpatrick, P.F.
Analysis of the roles of amino acid residues in the flavoprotein tryptophan 2-monooxygenase modified by 2-oxo-3-pentynoate: characterization of His338, Cys339, and Cys511 mutant enzymes
Arch. Biochem. Biophys.
402
24-30
2002
Pseudomonas savastanoi
Manually annotated by BRENDA team
Emanuele, J.J.; Heasley, C.J.; Fitzpatrick, P.F.
Purification and characterization of the flavoprotein tryptophan 2-monooxygenase expressed at high levels in Escherichia coli
Arch. Biochem. Biophys.
316
241-248
1995
Pseudomonas savastanoi
Manually annotated by BRENDA team
Gadda, G.; Dangott, L.J.; Johnson, W.H., Jr.; Whitman, C.P.; Fitzpatrick, P.F.
Characterization of 2-oxo-3-pentynoate as an active-site-directed inactivator of flavoprotein oxidase: identification of active-site peptides in tryptophan 2-monooxygenase
Biochemistry
38
5822-5828
1999
Pseudomonas savastanoi
Manually annotated by BRENDA team
Lemcke, K.; Prinsen, E.; van Onckelen, H.; Schmulling, T.
The ORF8 gene product of Agrobacterium rhizogenes TL-DNA has tryptophan 2-monooxygenase activity
Mol. Plant Microbe Interact.
13
787-790
2000
Agrobacterium rhizogenes
Manually annotated by BRENDA team
Sobrado, P.; Fitzpatrick, P.F.
Analysis of the role of the active site residue Arg98 in the flavoprotein tryptophan 2-monooxygenase, a member of the L-amino oxidase family
Biochemistry
42
13826-13832
2003
Pseudomonas savastanoi
Manually annotated by BRENDA team
Sobrado, P.; Fitzpatrick, P.F.
Identification of Tyr413 as an active site residue in the flavoprotein tryptophan 2-monooxygenase and analysis of its contribution to catalysis
Biochemistry
42
13833-13838
2003
Pseudomonas savastanoi
Manually annotated by BRENDA team
Ralph, E.C.; Anderson, M.A.; Cleland, W.W.; Fitzpatrick, P.F.
Mechanistic studies of the flavoenzyme tryptophan 2-monooxygenase: deuterium and (15)N kinetic isotope effects on alanine oxidation by an l-amino acid oxidase
Biochemistry
45
15844-15852
2006
Pseudomonas savastanoi
Manually annotated by BRENDA team
Mujahid, M.; Sasikala, C.; Ramana, C.
Production of indole-3-acetic acid and related indole derivatives from L-tryptophan by Rubrivivax benzoatilyticus JA2
Appl. Microbiol. Biotechnol.
89
1001-1008
2011
Rubrivivax benzoatilyticus
Manually annotated by BRENDA team
Gaweska, H.M.; Taylor, A.B.; Hart, P.J.; Fitzpatrick, P.F.
Structure of the flavoprotein tryptophan 2-monooxygenase, a key enzyme in the formation of galls in plants
Biochemistry
52
2620-2626
2013
Pseudomonas savastanoi (P06617), Pseudomonas savastanoi
Manually annotated by BRENDA team
Yin, C.; Park, J.; Gang, D.; Hulbert, S.
Characterization of a tryptophan 2-monooxygenase gene from Puccinia graminis f. sp. tritici involved in auxin biosynthesis and rust pathogenicity
Mol. Plant Microbe Interact.
27
227-235
2014
Puccinia graminis f. sp. tritici (E3KNM7), Puccinia graminis f. sp. tritici CRL 75-36-700-3 (E3KNM7)
Manually annotated by BRENDA team
Mujahid, M.; Sasikala, C.h.; Ramana, C.h.V.
Aniline is an inducer, and not a precursor, for indole derivatives in Rubrivivax benzoatilyticus JA2
PLoS ONE
9
e87503
2014
Rubrivivax benzoatilyticus, Rubrivivax benzoatilyticus JA2
Manually annotated by BRENDA team
Zhang, Y.; Lee, C.; Wehner, N.; Imdahl, F.; Svetlana, V.; Weiste, C.; Droege-Laser, W.; Deeken, R.
Regulation of oncogene expression in T-DNA-transformed host plant cells
PLoS Pathog.
11
1-27
2015
Agrobacterium tumefaciens (Q9R717), Agrobacterium tumefaciens C58 (Q9R717)
Manually annotated by BRENDA team