1.13.12.3: tryptophan 2-monooxygenase

This is an abbreviated version, for detailed information about tryptophan 2-monooxygenase, go to the full flat file.

Reaction

L-tryptophan
+
O2
=
(indol-3-yl)acetamide
+
CO2
+
H2O

Synonyms

IaaM, oxygenase, tryptophan 2-mono-, Pgt-IaaM, PGTG_11658, TMO, tryptophan 2-monooxygenase, tryptophan monooxygenase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
                1.13.12.3 tryptophan 2-monooxygenase

Substrates Products

Substrates Products on EC 1.13.12.3 - tryptophan 2-monooxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5-hydroxytryptophan + O2
5-hydroxyindole-3-acetamide + CO2 + H2O
show the reaction diagram
-
at 17% the rate of that for L-tryptophan
-
-
?
5-methyltryptophan + O2
5-methylindole-3-acetamide + CO2 + H2O
show the reaction diagram
-
-
-
-
?
D,L-3-phenyl-2-hydrazinopropanoic acid + O2
2-phenylacetohydrazide + CO2 + H2O
show the reaction diagram
-
-
-
-
?
D,L-3-pyridylalanine + O2
2-pyridylacetamide + CO2 + H2O
show the reaction diagram
-
-
-
-
?
D,L-N-methyl-phenylalanine + O2
N-methyl-2-phenylacetamide + CO2 + H2O
show the reaction diagram
-
-
-
-
?
L-alanine + O2
acetamide + CO2 + H2O
show the reaction diagram
L-methionine + O2
3-(methylthio)propanamide + CO2 + H2O
show the reaction diagram
-
-
-
-
?
L-phenylalanine + O2
phenylacetamide + CO2 + H2O
show the reaction diagram
L-tryptophan + O2
(indol-3-yl)acetamide + CO2 + H2O
show the reaction diagram
L-tryptophan + O2
?
show the reaction diagram
-
oxidative decarboxylation of L-tryptophan during the biosynthesis of indoleacetic acid
-
-
?
L-tryptophan + O2
indole-3-acetamide + CO2 + H2O
show the reaction diagram
L-tyrosine + O2
4-hydroxyphenylacetamide + CO2 + H2O
show the reaction diagram
-
weak activity
-
-
?
additional information
?
-
-
no activity with: indole-3-pyruvate, indole-3-acetaldehyde, alpha-methyltryptophan, indole-3-acetic acid
-
-
-