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1.14.11.1: gamma-butyrobetaine dioxygenase

This is an abbreviated version!
For detailed information about gamma-butyrobetaine dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.1

Reaction

4-Trimethylammoniobutanoate
+
2-oxoglutarate
+
O2
=
3-hydroxy-4-trimethylammoniobutanoate
+
succinate
+
CO2

Synonyms

4-trimethylaminobutyric acid dioxygenase, alpha-butyrobetaine hydroxylase, BBD, BBH, BBOX, BBOX1, Bu hydroxylase, butyrobetaine hydroxylase, gamma butyrobetaine hydroxylase, gamma-BBD, gamma-BBH, gamma-buryrobetaine dioxygenase, gamma-butyrobetaine dioxygenase, gamma-butyrobetaine hydroxylase, gamma-butyrobetaine hydroxylase 1, GBB hydroxylase, GBBH, hBBOX, oxygenase, gamma-butyrobetaine di-, psBBOX

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.1 gamma-butyrobetaine dioxygenase

Expression

Expression on EC 1.14.11.1 - gamma-butyrobetaine dioxygenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
activity of gamma-butyrobetaine dioxygenase lowest at birth in liver and kidney, but increase until age of 2 weeks
-
detection of mRNA levels during suckling period onwards, expression is ontogenically regulated
hepatic activity is low at birth but increases after 1 day. By 21 days, the activity rises by 6.6fold and remains constant after 56 days. Renal activity is higher than in liver at birth but remains constant through 35 days. By 56 days, the velocity increases by 44% over the activity at birth
highest mRNA concentrations in epididymis and in kidney. In heart, colon, small intestine, lung, spleen, testes and brain lower mRNA levels compared to liver. In skeletal muscle almost absent mRNA amount
-