1.14.11.1: gamma-butyrobetaine dioxygenase

This is an abbreviated version!
For detailed information about gamma-butyrobetaine dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.1

1.14.11.1

cardioprotective

carnitine-dependent

3-2,2,2-trimethylhydrazinium

mildronate

trimethyllysine

mid1

alpha4

medicine

d-carnitine

dihydrate

drug development

molecular biology

Reaction

4-Trimethylammoniobutanoate

+

2-oxoglutarate

+

O2

=

3-hydroxy-4-trimethylammoniobutanoate

+

succinate

+

CO2

Synonyms

4-trimethylaminobutyric acid dioxygenase, alpha-butyrobetaine hydroxylase, BBD, BBH, BBOX, BBOX1, Bu hydroxylase, butyrobetaine hydroxylase, gamma butyrobetaine hydroxylase, gamma-BBD, gamma-BBH, gamma-buryrobetaine dioxygenase, gamma-butyrobetaine dioxygenase, gamma-butyrobetaine hydroxylase, gamma-butyrobetaine hydroxylase 1, GBB hydroxylase, GBBH, hBBOX, oxygenase, gamma-butyrobetaine di-, psBBOX

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.1 gamma-butyrobetaine dioxygenase

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Results	in table
27	Activating Compound
1493	AA Sequence
7	Application
1	CAS Registry Number
8	Cloned(Commentary)
15	Cofactor
4	Crystallization (Commentary)
46	Disease/ Diagnostics
4	Expression
26	General Information
4	General Stability
80	IC50 Value
157	Inhibitors
7	Ki Value [mM]
53	KM Value [mM]
15	Localization
25	Metals/Ions
13	Molecular Weight [Da]
16	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
88	Organism
2	Oxidation Stability
6	Pathway
17	PDB ID
9	pH Optimum
2	pH Range
14	Purification (Commentary)
4	Reaction
4	Reaction Type
55	Reference
61	Source Tissue
20	Specific Activity [micromol/min/mg]
5	Storage Stability
91	Substrates and Products (Substrate)
18	Subunits
51	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
2	Temperature Stability [°C]
18	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.14.11.1 - gamma-butyrobetaine dioxygenase

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0.0038

(E)-4-(trimethylammonio)but-2-enoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.117

1,1,1-trimethyl-2-(2-phosphonoethyl)hydrazin-1-ium Iodide

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.00049

1-(3-carboxypropyl)-1-methylpyrrolidin-1-ium

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

1

1-(3-carboxypropyl)pyrrolidin-1-ium

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.087

2-(1,1,1-trimethylhydrazin-1-ium-2-yl)ethanesulfonate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

1

2-(2-carboxyethyl)-1,1-diethyl-1-methylhydrazin-1-ium chloride

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.024

2-(2-carboxyethyl)-1,1-dimethyl-1-(prop-2-yn-1-yl)-hydrazin-1-ium bromide

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.0102

2-(2-carboxyethyl)-1-(2-chloroethyl)-1,1-dimethylhydrazin-1-ium bromide

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.00009

3-(1,1,1,2-tetramethylhydrazin-1-ium-2-yl)propanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.0031

3-(1,1,2-trimethyl-1-propylhydrazin-1-ium-2-yl)propanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.0068

3-(1,1-dimethyl-1-vinylhydrazin-1-ium-2-yl)propanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

-

0.119

3-(1-allyl-1,1-dimethylhydrazin-1-ium-2-yl)propanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.0072

3-(1-ethyl-1,1,2-trimethylhydrazin-1-ium-2-yl)propanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.14

3-(1-ethyl-1,1-dimethylhydrazin-1-ium-2-yl)propanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

1

3-(1-isopropyl-1,1-dimethylhydrazin-1-ium-2-yl)propanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.062

3-(2,2,2-trimethylhydrazinium propionate dihydrate)

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.0028

3-(2-ethyl-1,1,1-trimethylhydrazin-1-ium-2-yl)propanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.0067

3-(ethyldimethylammonio)propane-1-sulfonate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

1

3-(trimethylammonio)cyclohexanecarboxylate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.0017

3-(trimethylammonio)propane-1-sulfonate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.459

3-carboxy-2-chloro-N,N,N-trimethylpropan-1-aminium

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.00026

3-carboxy-N-(2-chloroethyl)-N,N-dimethylpropan-1-aminium

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.00061

3-carboxy-N-(2-fluoroethyl)-N,N-dimethylpropan-1-aminium

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

1

3-hydroxy-N-(2-phenylethyl)pyridine-2-carboxamide

Homo sapiens

above, pH and temperature not specified in the publication

1

3-[1-(2-aminoethyl)-1,1-dimethylhydrazin-1-ium-2-yl]-propanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

1

3-[1-(2-hydroxyethyl)-1,1-dimethylhydrazin-1-ium-2-yl]-propanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

-

0.0027

4-(allyldimethylammonio)butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

1

4-(benzyldimethylammonio)butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

1

4-(butyldimethylammonio)butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.00081

4-(cyclobutyldimethylammonio)butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

1

4-(cyclopentyldimethylammonio)butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.0021

4-(cyclopropyldimethylammonio)butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.388

4-(dimethylsulfonio)butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.0033

4-(ethyldimethylammonio)butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.343

4-(trimethylammonio)pentanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.015

4-([(2E)-3-carboxyprop-2-enoyl](hydroxy)amino)-N,N,N-trimethylbutan-1-aminium

Homo sapiens

pH and temperature not specified in the publication

-

1

4-[(2-hydroxyethyl)dimethylammonio]butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

1

4-[(bromomethyl)dimethylammonio]butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.268

4-[(chloromethyl)dimethylammonio]butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

1

4-[(cyclobutylmethyl)dimethylammonio]butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

1

4-[(cyclopropylmethyl)dimethylammonio]butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

1

4-[(iodomethyl)dimethylammonio]butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

1

4-[(methoxymethyl)dimethylammonio]butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.1

4-[diethyl(methyl)ammonio]butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.0014

4-[dimethyl(prop-2-yn-1-yl)ammonio]butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

1

4-[dimethyl(propyl)ammonio]butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.127

4-[dimethyl(vinyl)ammonio]butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.0057

4-[isopropyl(dimethyl)ammonio]butanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

1

5-(trimethylammonio)pentanoate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.000153

AR692B

Homo sapiens

pH and temperature not specified in the publication

0.019

benzeneselenenic acid

Homo sapiens

pH 7.0, 22°C, 20 min

0.003

benzeneselenenyl bromide

Homo sapiens

pH 7.0, 22°C, 20 min

0.0029

benzeneselenenyl chloride

Homo sapiens

pH 7.0, 22°C, 20 min

0.0047

benzeneseleninic acid

Homo sapiens

pH 7.0, 22°C, 20 min

0.042

diphenyldiselane

Homo sapiens

pH 7.0, 22°C, 20 min

0.00083

ebselen

Homo sapiens

pH 7.0, 22°C, 20 min

0.0009

Isoquinoline

Homo sapiens

pH and temperature not specified in the publication

0.06

mildronate

Homo sapiens

pH and temperature not specified in the publication

1

N,N,N-trimethyl-3-(1H-tetrazol-5-yl)propan-1-aminium

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.0001

N,N,N-trimethyl-3-phosphonopropan-1-aminium

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.026

N-(1-chloro-4-hydroxyisoquinoline-3-carbonyl)-L-tryptophan

Homo sapiens

pH 7.5, temperature not specified in the publication, recombinant enzyme

0.0012 - 0.018

N-(1-chloro-4-hydroxyisoquinoline-3-carbonyl)glycine

show

0.0012

N-(2-bromoethyl)-3-carboxy-N,N-dimethylpropan-1-aminium

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.088

N-(2-hydroxybenzoyl)-L-phenylalanine

Homo sapiens

pH and temperature not specified in the publication

0.537

N-(2-hydroxybenzoyl)glycine

Homo sapiens

pH and temperature not specified in the publication

0.522

N-(3-hydroxypyridine-2-carbonyl)-beta-alanine

Homo sapiens

pH and temperature not specified in the publication

0.15

N-(3-hydroxypyridine-2-carbonyl)-D-phenylalanine

Homo sapiens

pH and temperature not specified in the publication

0.0018

N-(3-hydroxypyridine-2-carbonyl)-L-glutamic acid

Homo sapiens

pH and temperature not specified in the publication

0.0005 - 0.002

N-(3-hydroxypyridine-2-carbonyl)-L-phenylalanine

show

0.0002

N-(3-hydroxypyridine-2-carbonyl)-S-[(pyridin-2-yl)methyl]-L-cysteine

Homo sapiens

pH and temperature not specified in the publication

0.006 - 1

N-(3-hydroxypyridine-2-carbonyl)glycine

show

0.0125

N-(pyridine-2-carbonyl)-L-phenylalanine

Homo sapiens

pH and temperature not specified in the publication

0.032

N-[(1-chloro-4-hydroxy-3-isoquinolinyl)carbonyl]-glycine

Homo sapiens

pH 7.0, 22°C, 20 min

0.082

Pyridine 2,4-dicarboxylate

Homo sapiens

-

pH 7.5, 25°C

0.0079

thiram

Homo sapiens

pH 7.0, 22°C, 20 min

0.00053

[3-(ethyldimethylammonio)propyl]phosphinate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

0.00052

[3-(trimethylammonio)propyl]phosphinate

Homo sapiens

pH 7.0, 37°C, recombinant enzyme

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Release 2023.1 (January 2023)