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1.14.11.2: procollagen-proline 4-dioxygenase

This is an abbreviated version!
For detailed information about procollagen-proline 4-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.2

Reaction

Procollagen L-proline
+
2-oxoglutarate
 +
O2
=
procollagen trans-4-hydroxy-L-proline
 +
succinate
 +
CO2

Synonyms

A085R, alpha (I) subunit, anthrax-P4H, AT-P4H-1, At-P4H-2, BaP4H, C-P4H, C-P4H alpha subunit (III), C-P4H alpha(I), C-P4H alpha(III), CePHY-1/PHY-2/PDI2, collagen proline hydroxylase, collagen prolyl 4-hydroxylase, collagen prolyl 4-hydroxylase (type-II), collagen prolyl 4-hydroxylase 1, collagen prolyl-4-hydroxylase, collagen prolyl-4-hydroxylase alpha subunit 2, CP4H, CP4H1, CrP4H-1, DmP4H, egg-laying abnormal-9 prolyl hydroxylase, Egl nine homolog, EGLN, EGLN prolyl hydroxylase, EGLN3, EGLN3 hydroxylase, GBAA_4459, HIF prolyl hydroxylase, HIF prolyl-4-hydroxylase, HIF-1alpha-specific prolyl-hydroxylase, HIF-P4H-1, HIF-P4H-2, HIF-P4H-3, HPH, HPH-2, HuPH4-I, HuPH4-II, hydroxylase, collagen proline, hypoxia inducible factor prolyl-4-hydroxylase domain-containing protein, hypoxia inducible factor-prolyl hydroxylase, hypoxia-inducible factor -1alpha-type prolyl 4-hydroxylase, hypoxia-inducible factor prolyl hydroxylase, hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2, More, NtP4H1.1, P4H, P4H alpha1, P4H-1, P4H1, P4ha1, P4ha2, P4Halpha(I), P4Halpha(II), P4Halpha(III), P4Halpha1, PBCV-1 P4H, peptidyl proline hydroxylase, PH, PHD, PHD-1, PHD1, PHD2, PHD3, procollagen prolyl 4-hydroxylase, procollagen-proline dioxygenase, proline 4-hydroxylase, proline hydroxylase, proline protocollagen hydroxylase, proline, 2-oxoglutarate dioxygenase, proline,2-oxoglutarate 4-dioxygenase, prolyl 4-hydroxylase, prolyl 4-hydroxylase A085R, prolyl hydroxylase, prolyl hydroxylase domain 1, prolyl hydroxylase domain containing protein, prolyl hydroxylase domain enzyme, prolyl hydroxylase domain protein 2, prolyl hydroxylase-1, prolyl hydroxylase-3, prolyl-4-hydroxylase, prolyl-4-hydroxylase alpha I, prolyl-4-hydroxylase alpha II, prolyl-4-hydroxylase alpha subunit 2, prolyl-4-hydroxylase alpha1, prolyl-4-hydroxylase-alpha1, prolyl-4-hydroxylases, prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating, prolyl4-hydroxylase, prolylprotocollagen dioxygenase, prolylprotocollagen hydroxylase, protocollagen hydroxylase, protocollagen proline 4-hydroxylase, protocollagen proline dioxygenase, protocollagen proline hydroxylase, protocollagen prolyl hydroxylase, PSB-II, Skp1 prolyl hydroxylase, type I C-P4H, type I proly 4-hydroxylase, type I proyl 4-hydroxylase, type II proyl 4-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.2 procollagen-proline 4-dioxygenase

Expression

Expression on EC 1.14.11.2 - procollagen-proline 4-dioxygenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
after apoptosis of H9c2 cells is induced by DOX, PHD3 expression is upregulated in a time-dependent manner, whereas the expression of PHD1 or PHD2 is constant
-
endothelin-1 inhibits PHD2 expression and promoter activity by 50% to stabilize HIF-alpha. HIF-1alpha and HIF-2alpha accumulation in response to endothelins is specifically impaired in PHD2 overexpressing cells, indicating that re-expression of PHD2 is sufficient to counteract the ET-1- or ET-3-induced HIF-alpha expression
-
in mycelia, all P4Hs are downregulated in response to hypoxia, but the expression of PcP4H1 is most affected. Pc4H1 is upregulated more than 110fold at the onset of infection, and Pc4H5 is upregulated 7fold, while the expression of other P4Hs is unchanged
mechanical stretch increases MMP-2 and P4H alpha1 expression in human aortic smooth muscle cell via AKT-P38 MAPK-JNK signaling, thereby inducing vascular remodeling. p38 MAPK inhibitor SB203580 and JNK inhibitor SP600125 significantly attenuates the stretch-induced upregulation of P4H alpha1 expression, whereas blockade of the ERK1/2 pathway has no effect on P4H alpha1 expression
P4H alpha 1 subunit (P4HA1) protein expression is induced in triple-negative breast cancer (TNBC) and HER2 positive breast cancer
P4H alphaII or alphaIII null mice with 20% of wild-type enzyme activity do not show an abnormal phenotype, while P4H alpha I null mutants die at day E10.5 and show an overall developmental delay and rupture of the basement membranes due to a lack of collgane IV, overview
-
PHD2 is hypoxia-inducible by HIF-1alpha
-
the activity of the enzyme (P4H) in liver and swim bladder shows similar trend, showing first increase and then decrease with increasing dietary hydroxyproline. Increased dietary hydroxyproline content corresponds with significant decrease in the mRNA level of P4Halphas in swim bladder
-
the enzyme is induced by mechanical stretch on the vessel wall, an important stimulus that also induces collagen remodeling
the expressions of P4HAs and P4HB are regulated by multiple cellular factors, including cytokines, transcription factors, and microRNAs. P4HAs and P4HB are highly expressed in many tumors. P4HB expression is significantly upregulated in a variety of cancers, including HCC, RCC, glioma, GC, and melanoma, and its upregulation correlates with cancer metastasis and invasion