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1.14.11.21: clavaminate synthase

This is an abbreviated version!
For detailed information about clavaminate synthase, go to the full flat file.

Word Map on EC 1.14.11.21

Reaction

deoxyamidinoproclavaminate
+
2-oxoglutarate
 +
O2
=
amidinoproclavaminate
 +
succinate
 +
CO2

Synonyms

CAS, CAS1, CAS2, clavaminate synthase 1, clavaminate synthase 2, clavaminic acid synthase, CS, synthase, clavaminate

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.21 clavaminate synthase

Inhibitors

Inhibitors on EC 1.14.11.21 - clavaminate synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4'-ethynyl proclavaminate
-
noncompetitive
4'-vinyl proclavaminate
-
noncompetitive
4-cyclopropyl proclavaminate
-
noncompetitive
ascorbate
-
inactivation due to release of peroxide from reaction of ascorbate and O2 in absence of proclavaminate, but in presence of Fe2+, t1/2: 50 min, catalase protects
diethyl dicarbonate
-
isozyme CS2, rapid inactivation at pH 6.0, 25°C, t1/2: 1.1 min
N-bromoacetyl-L-arginine
-
isozyme CS2, inactivation, at 7.5 mM half-life of 11.2 min at 30°C, Co2+ competes, substrates protect
N-ethylmaleimide
-
inactivation