1.14.11.27: [histone-H3]-lysine-36 demethylase

This is an abbreviated version, for detailed information about [histone-H3]-lysine-36 demethylase, go to the full flat file.

Reaction

protein N6,N6-dimethyl-L-lysine
+
2-oxoglutarate
+
O2
=
protein N6-methyl-L-lysine
+
succinate
+
formaldehyde
+
CO2

Synonyms

CG33182, CG33185, dJMJD2(1), dJMJD2(1)/CG15835, dJMJD2(2), dJMJD2(2)/CG33182, dKDM2, dKDM4A, dRAF, H3-K36 demethylase, H3-K36-specific demethylase, H3K36 demethylase, H3K36 histone demethylase, H3K36me2 demethylase, H3K36me2 histone demethylase, H3K36me2-specific demethylase, H3K9/36me3 lysine demethylase, histone demethylase JmjD2A, histone H3 lysine 36 demethylase, histone H3 lysine 36 dimethyl–specific demethylase, histone H3K36 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone-lysine(H3-K36) demethylase, Jhd1, JHDM1A, Jhdm1b/Kdm2b, JmjC domain histone demethylase, JmjC domain-containing histone demethylase 1, JmjC domain-containing histone demethylase 1A, JmjC domain-containing histone demethylation protein 3A, JmjC domain-containing histone demethylation protein 3b, JmjC protein, JmjC+N, JmjC+N histone demethylase, JMJD2, JMJD2A, JMJD2B, JMJD2D, JMJD5, KDM2B, KDM2b/JHDM1b, KDM4, KDM4A, KDM4A demethylase, KDM4A/JMJD2A, KDM8, More, Ndy1, PfJmjC1, Rph1, Rph1/KDM4, scJHDM1, [histone-H3]-lysine-36 demethylase 1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.27 [histone-H3]-lysine-36 demethylase

Cloned

Cloned on EC 1.14.11.27 - [histone-H3]-lysine-36 demethylase

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
characterization of dKDM4A alleles, and the dKDM4A genomic locus, the dKDM4A locus contains four exons, overview. Quantitative RT-PCR of dKDM4A expression analysis of wild-type and mutant enzymes in larvae
-
DNA and amino acid sequence determination and analysis, chromosomal location and association analysis , the porcine JHDM1A gene encodes 1,162 amino acids and contains JmjC, F-box, and CXXC zinc-finger domains, which coding sequence and deduced protein shares 91 and 99% similarity with human JHDM1A, respectively
-
ectopic expression of either wild-type Jhdm1a or H212A point mutant in the liver of diabetic ob/ob mice
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ectopic expression of Jhdm1a in HeLa and wild-type and enzyme-deficient Hep-G2 cells via lentivirus transfection
-
enzyme overexpression in HEK-293T cells, phenotype,, overview
-
expression analysis by quantitative reverse transcriptase PCR, overexpression of wild-type Jhdm1b in HeLa and HEK293 cells
expression in Escherichia coli, His-tagged
-
expression in mouse embryo fibroblast
-
expression of FLAG-tagged JMJD2A in Spodoptera frugiperda Sf9 cells
-
expression of Flag-tagged protein
expression of fusion proteins His6-Smt3-JMJD5183–416 and His6-Smt3-JMJD52–416 in Escherichia coli strain BL21 Rosetta2 DE3
expression of GFP-tagged JmjD2A under the control beta-actin promoter in chicken fibroblasts
-
expression of N-terminally His-tagged KDM4A in Escherichia coli; expression of N-terminally His-tagged KDM4B in Escherichia coli; expression of N-terminally His-tagged KDM4C in Escherichia coli
expression of wild-type and mutant dKDM4A in Spodoptera frugiperda Sf21 cells using baculovirus transfection
gene dkdm4a, expression of FLAG-tagged wild-type and V423A mutant enzymes
-
gene Jmjd5, FLAG-His6 tagged mutant H319A is cloned into the pDON-5 Neo plasmid to produce retroviruses, shRNA-expressing retroviruses are used for silencing of the enzyme, expression of C-terminally His-tagged JMJD5 in Escherichia coli, quantitative reverse transcription PCR expression analysis
-
gene MAL8P1.111, located on chromosome 8, DNA and amino acid sequence determination and analysis, detailed phylogenetic analysis, overview
-
Ndy1 overexpression in mouse embryonic fibroblasts, quantitative real-time reverse transcriptase PCR expression analysis
-
overexpression of FLAG-tagged CG15835 in S2 cells