1.14.11.27: [histone-H3]-lysine-36 demethylase

This is an abbreviated version!
For detailed information about [histone-H3]-lysine-36 demethylase, go to the full flat file.

Word Map on EC 1.14.11.27

Reaction

protein N6,N6-dimethyl-L-lysine
+ 2 2-oxoglutarate + 2 O2 =
protein L-lysine
+ 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

AN1060, CG33182, CG33185, dJMJD2(1), dJMJD2(1)/CG15835, dJMJD2(2), dJMJD2(2)/CG33182, dKDM2, dKDM4A, dRAF, GASC1, Gis1, H3-K36 demethylase, H3-K36-specific demethylase, H3K36 demethylase, H3K36 histone demethylase, H3K36me2 demethylase, H3K36me2 histone demethylase, H3K36me2-specific demethylase, H3K9/36me3 lysine demethylase, H3K9/H3K36 histone demethylase, histone demethylase, histone demethylase JmjD2A, histone H3 demethylase, histone H3 lysine 36 demethylase, histone H3 lysine 36 dimethyl–specific demethylase, histone H3K36 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone-lysine(H3-K36) demethylase, histoneH3 demethylase, Jhd1, JHDM1A, Jhdm1b/Kdm2b, JmjC demethylase, JmjC domain histone demethylase, JmjC domain lysine demethylase, JmjC domain-containing histone demethylase 1, JmjC domain-containing histone demethylase 1A, JmjC domain-containing histone demethylation protein 3A, JmjC domain-containing histone demethylation protein 3b, JmjC histone lysine demethylase, JmjC protein, JmjC+N, JmjC+N histone demethylase, JMJD2, Jmjd2 demethylase, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD5, JumonjiC demethylase, KDM2B, KDM2b/JHDM1b, KDM4, KDM4A, KDM4A demethylase, KDM4A/JMJD2A, KDM4B, Kdm4c, KDM4D, KDM8, KdmA, lysine demethylase, More, Ndy1, PfJmjC1, Rph1, Rph1/KDM4, scJHDM1, [histone-H3]-lysine-36 demethylase 1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.27 [histone-H3]-lysine-36 demethylase

Engineering

Engineering on EC 1.14.11.27 - [histone-H3]-lysine-36 demethylase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H195A
V423A
-
site-directed mutagenesis, the point mutation at the central valine of PxVxL motif disrupts the interaction between dKDM4A and HP1a in vitro
H188A
-
inactive mutant
H212A
-
mutation completely abolishes the enzymatic activity
R919D
site-directed mutagenesis, the mutant is not associated with mitotic chromatin in contrast to the wild-type enzyme
S198M
site-directed mutagenesis, a KDM4C demethylase dead mutant
S288A
H211A
inactive mutant
H212A
-
inactive mutant
H319A
-
a catalytically inactive mutant
H212A
-
inactive mutant
-
H235A
-
catalytically deficient mutant
H305A
T302A
more than 90% loss of activity
Y315A
more than 90% loss of activity
H235A
-
catalytically deficient mutant
-
additional information