Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.11.27: [histone H3]-dimethyl-L-lysine36 demethylase

This is an abbreviated version!
For detailed information about [histone H3]-dimethyl-L-lysine36 demethylase, go to the full flat file.

Word Map on EC 1.14.11.27

Reaction

a [histone H3]-N6,N6-dimethyl-L-lysine36
+ 2 2-oxoglutarate + 2 O2 =
a [histone H3]-L-lysine36
+ 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

dKDM2, dKDM4A, dRAF, GASC1, H3-K36 demethylase, H3-K36-specific demethylase, H3K36 demethylase, H3K36me2 demethylase, H3K36me2 histone demethylase, H3K36me2-specific demethylase, histone H3 lysine 36 demethylase, histone H3 lysine 36 dimethylspecific demethylase, histone-lysine(H3-K36) demethylase, Jhd1, JHDM1A, Jhdm1b/Kdm2b, JmjC domain histone demethylase, JmjC domain-containing histone demethylase 1, JmjC domain-containing histone demethylase 1A, JmjC domain-containing histone demethylation protein 1, JMJD2, JMJD2A, JMJD5, JMJD7, Kdm2a, KDM2B, KDM2b/JHDM1b, KDM4, KDM4A, KDM4B, Kdm4c, KDM4D, KDM8, lysine demethylase, More, Ndy1, PfJmjC1, PfSET1, scJHDM1, SET1, [histone-H3]-lysine-36 demethylase 1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.27 [histone H3]-dimethyl-L-lysine36 demethylase

Engineering

Engineering on EC 1.14.11.27 - [histone H3]-dimethyl-L-lysine36 demethylase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H188A
inactive
H212A
-
mutation completely abolishes the enzymatic activity
R919D
site-directed mutagenesis, the mutant is not associated with mitotic chromatin in contrast to the wild-type enzyme
S198M
site-directed mutagenesis, a KDM4C demethylase dead mutant
H211A
inactive mutant
H212A
-
inactive mutant
H319A
-
a catalytically inactive mutant
H212A
-
inactive mutant
-
H305A
T302A
more than 90% loss of activity
Y315A
more than 90% loss of activity
additional information