1.14.11.27: [histone-H3]-lysine-36 demethylase

This is an abbreviated version!
For detailed information about [histone-H3]-lysine-36 demethylase, go to the full flat file.

Word Map on EC 1.14.11.27

Reaction

protein N6,N6-dimethyl-L-lysine
+ 2 2-oxoglutarate + 2 O2 =
protein L-lysine
+ 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

AN1060, CG33182, CG33185, dJMJD2(1), dJMJD2(1)/CG15835, dJMJD2(2), dJMJD2(2)/CG33182, dKDM2, dKDM4A, dRAF, GASC1, Gis1, H3-K36 demethylase, H3-K36-specific demethylase, H3K36 demethylase, H3K36 histone demethylase, H3K36me2 demethylase, H3K36me2 histone demethylase, H3K36me2-specific demethylase, H3K9/36me3 lysine demethylase, H3K9/H3K36 histone demethylase, histone demethylase, histone demethylase JmjD2A, histone H3 demethylase, histone H3 lysine 36 demethylase, histone H3 lysine 36 dimethylspecific demethylase, histone H3K36 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone-lysine(H3-K36) demethylase, histoneH3 demethylase, Jhd1, JHDM1A, Jhdm1b/Kdm2b, JmjC demethylase, JmjC domain histone demethylase, JmjC domain lysine demethylase, JmjC domain-containing histone demethylase 1, JmjC domain-containing histone demethylase 1A, JmjC domain-containing histone demethylation protein 3A, JmjC domain-containing histone demethylation protein 3b, JmjC histone lysine demethylase, JmjC protein, JmjC+N, JmjC+N histone demethylase, JMJD2, Jmjd2 demethylase, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD5, JumonjiC demethylase, KDM2B, KDM2b/JHDM1b, KDM4, KDM4A, KDM4A demethylase, KDM4A/JMJD2A, KDM4B, Kdm4c, KDM4D, KDM8, KdmA, lysine demethylase, More, Ndy1, PfJmjC1, Rph1, Rph1/KDM4, scJHDM1, [histone-H3]-lysine-36 demethylase 1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.27 [histone-H3]-lysine-36 demethylase

IC50 Value

IC50 Value on EC 1.14.11.27 - [histone-H3]-lysine-36 demethylase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.037
2-(2-((chroman-6-ylmethyl)amino)pyrimidin-4-yl)isonicotinic acid
Homo sapiens
-
pH 7.5, 37C
0.003
3-(9-(dimethylamino)-N-hydroxynonanamido)propanoic acid
Homo sapiens
-
pH 7.5, 37C
0.2
3-[hydroxy-[5-[[(1R)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-5-oxo-pentanoyl]amino]propanoic acid
Homo sapiens
-
above, pH 7.5, 37C
0.0703
3-[hydroxy-[5-[[(1S)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-5-oxo-pentanoyl]amino]propanoic acid
Homo sapiens
-
pH 7.5, 37C
0.0606
3-[hydroxy-[7-[[(1S)-2-methoxy-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-7-oxo-heptanoyl]amino]propanoic acid
Homo sapiens
-
pH 7.5, 37C
0.0068
3-[hydroxy-[8-[[(1R)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-8-oxo-octanoyl]amino]propanoic acid
Homo sapiens
-
pH 7.5, 37C
0.0136
3-[hydroxy-[8-[[(1S)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-8-oxo-octanoyl]amino]propanoic acid
Homo sapiens
-
pH 7.5, 37C
0.0371
3-[hydroxy-[8-[[(1S)-2-methoxy-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-8-oxo-octanoyl]amino]propanoic acid
Homo sapiens
-
pH 7.5, 37C
0.0466
5-tetrazolyl acetohydrazide
Homo sapiens
-
pH 7.5, 37C
0.0085
8-(hydroxyamino)-N-[(1S)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]-8-oxo-octanamide
Homo sapiens
-
pH 7.5, 37C
0.0258
methyl (2S)-2-[[4-[3-(hydroxyamino)-3-oxo-propyl]benzoyl]amino]-3-(4-phenylphenyl)propanoate
Homo sapiens
-
pH 7.5, 37C
0.0706
methyl (2S)-2-[[7-(hydroxyamino)-7-oxo-heptanoyl]amino]-3-(4-phenylphenyl)propanoate
Homo sapiens
-
pH 7.5, 37C
0.056
methyl (2S)-2-[[7-[hydroxy-(3-methoxy-3-oxo-propyl)amino]-7-oxo-heptanoyl]amino]-3-(4-phenylphenyl)propanoate
Homo sapiens
-
pH 7.5, 37C
0.0171
methyl (2S)-2-[[8-[hydroxy-(3-methoxy-3-oxo-propyl)amino]-8-oxo-octanoyl]amino]-3-(4-phenylphenyl)propanoate
Homo sapiens
-
pH 7.5, 37C
0.0563
methyl (S)-3-(2-chloro-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate
Homo sapiens
-
pH 7.5, 37C
-
0.0476
methyl (S)-3-(3'-cyano-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate
Homo sapiens
-
pH 7.5, 37C
-
0.029
methyl (S)-3-(3'-fluoro-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate
Homo sapiens
-
pH 7.5, 37C
0.0483
methyl (S)-3-(4'-chloro-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate
Homo sapiens
-
pH 7.5, 37C
0.0548
methyl (S)-3-(4'-cyano-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate
Homo sapiens
-
pH 7.5, 37C
0.0522
methyl (S)-3-(4'-fluoro-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate
Homo sapiens
-
pH 7.5, 37C
0.0939
methyl (S)-3-(6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate
Homo sapiens
-
pH 7.5, 37C
-
0.0254
methyl (S)-3-([1,1'-biphenyl]-4-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate
Homo sapiens
-
pH 7.5, 37C
0.0276
methyl 3-(3'-chloro-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate
Homo sapiens
-
pH 7.5, 37C
0.0068
methyl 3-[hydroxy-[8-[[(1S)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-8-oxo-octanoyl]amino]propanoate
Homo sapiens
-
pH 7.5, 37C
0.2
N-[(1S)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]heptanamide
Homo sapiens
-
above, pH 7.5, 37C
0.0145
N1-((3'-chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)-N8-hydroxyoctanediamide
Homo sapiens
-
above, pH 7.5, 37C
0.0188
N1-(2-(3'-chloro-6-hydroxy-[1,1'-biphenyl]-3-yl)ethyl)-N8-hydroxyoctanediamide
Homo sapiens
-
above, pH 7.5, 37C
0.0166
N1-(2-(3'-chloro-6-methoxy-[1,1'-biphenyl]-3-yl)ethyl)-N8-hydroxyoctanediamide
Homo sapiens
-
above, pH 7.5, 37C
0.0143
tert-butyl (2S)-2-[[8-(hydroxyamino)-8-oxo-octanoyl]amino]-3-(4-phenylphenyl)propanoate
Homo sapiens
-
pH 7.5, 37C
0.201
tert-butyl (2S)-2-[[8-(hydroxyamino)-8-oxo-octanoyl]amino]-3-phenyl-propanoate
Homo sapiens
-
pH 7.5, 37C