1.14.11.27: [histone-H3]-lysine-36 demethylase

This is an abbreviated version!
For detailed information about [histone-H3]-lysine-36 demethylase, go to the full flat file.

Word Map on EC 1.14.11.27

Reaction

protein N6,N6-dimethyl-L-lysine
+ 2 2-oxoglutarate + 2 O2 =
protein L-lysine
+ 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

AN1060, CG33182, CG33185, dJMJD2(1), dJMJD2(1)/CG15835, dJMJD2(2), dJMJD2(2)/CG33182, dKDM2, dKDM4A, dRAF, GASC1, Gis1, H3-K36 demethylase, H3-K36-specific demethylase, H3K36 demethylase, H3K36 histone demethylase, H3K36me2 demethylase, H3K36me2 histone demethylase, H3K36me2-specific demethylase, H3K9/36me3 lysine demethylase, H3K9/H3K36 histone demethylase, histone demethylase, histone demethylase JmjD2A, histone H3 demethylase, histone H3 lysine 36 demethylase, histone H3 lysine 36 dimethyl–specific demethylase, histone H3K36 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone-lysine(H3-K36) demethylase, histoneH3 demethylase, Jhd1, JHDM1A, Jhdm1b/Kdm2b, JmjC demethylase, JmjC domain histone demethylase, JmjC domain lysine demethylase, JmjC domain-containing histone demethylase 1, JmjC domain-containing histone demethylase 1A, JmjC domain-containing histone demethylation protein 3A, JmjC domain-containing histone demethylation protein 3b, JmjC histone lysine demethylase, JmjC protein, JmjC+N, JmjC+N histone demethylase, JMJD2, Jmjd2 demethylase, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD5, JumonjiC demethylase, KDM2B, KDM2b/JHDM1b, KDM4, KDM4A, KDM4A demethylase, KDM4A/JMJD2A, KDM4B, Kdm4c, KDM4D, KDM8, KdmA, lysine demethylase, More, Ndy1, PfJmjC1, Rph1, Rph1/KDM4, scJHDM1, [histone-H3]-lysine-36 demethylase 1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.27 [histone-H3]-lysine-36 demethylase

Reference

Reference on EC 1.14.11.27 - [histone-H3]-lysine-36 demethylase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tsukada, Y.; Fang, J.; Erdjument-Bromage, H.; Warren, M.E.; Borchers, C.H.; Tempst, P.; Zhang, Y.
Histone demethylation by a family of JmjC domain-containing proteins
Nature
439
811-816
2006
Homo sapiens, Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kim, T.; Buratowski, S.
Two Saccharomyces cerevisiae JmjC domain proteins demethylate histone H3 Lys36 in transcribed regions to promote elongation
J. Biol. Chem.
282
20827-20835
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Fang, J.; Hogan, G.J.; Liang, G.; Lieb, J.D.; Zhang, Y.
The Saccharomyces cerevisiae histone demethylase Jhd1 fine-tunes the distribution of H3K36me2
Mol. Cell. Biol.
27
5055-5065
2007
Saccharomyces cerevisiae (P40034), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Couture, J.; Collazo, E.; Ortiz-Tello, P.A.; Brunzelle, J.S.; Trievel, R.C.
Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase
Nat. Struct. Mol. Biol.
14
689-695
2007
Homo sapiens (O75164)
Manually annotated by BRENDA team
Ng, S.S.; Kavanagh, K.L.; McDonough, M.A.; Butler, D.; Pilka, E.S.; Lienard, B.M.; Bray, J.E.; Savitsky, P.; Gileadi, O.; von Delft, F.; Rose, N.R.; Offer, J.; Scheinost, J.C.; Borowski, T.; Sundstrom, M.; Schofield, C.J.; Oppermann, U.
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity
Nature
448
87-91
2007
Homo sapiens, Homo sapiens (O75164)
Manually annotated by BRENDA team
Lloret-Llinares, M.; Carre, C.; Vaquero, A.; de Olano, N.; Azorin, F.
Characterization of Drosophila melanogaster JmjC+N histone demethylases
Nucleic Acids Res.
36
2852-2863
2008
Drosophila melanogaster, Drosophila melanogaster (Q9V333), Drosophila melanogaster (Q9V6L0)
Manually annotated by BRENDA team
Chen, Z.; Zang, J.; Kappler, J.; Hong, X.; Crawford, F.; Wang, Q.; Lan, F.; Jiang, C.; Whetstine, J.; Dai, S.; Hansen, K.; Shi, Y.; Zhang, G.
Structural basis of the recognition of a methylated histone tail by JMJD2A
Proc. Natl. Acad. Sci. USA
104
10818-10823
2007
Homo sapiens (O75164)
Manually annotated by BRENDA team
Pfau, R.; Tzatsos, A.; Kampranis, S.C.; Serebrennikova, O.B.; Bear, S.E.; Tsichlis, P.N.
Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process
Proc. Natl. Acad. Sci. USA
105
1907-1912
2008
Rattus norvegicus
Manually annotated by BRENDA team
Marmorstein, R.; Trievel, R.C.
Histone modifying enzymes: structures, mechanisms, and specificities
Biochim. Biophys. Acta
1789
58-68
2009
Homo sapiens (O75164)
Manually annotated by BRENDA team
Li, Q.; Ke, Q.; Costa, M.
Alterations of histone modifications by cobalt compounds
Carcinogenesis
30
1243-1251
2009
Homo sapiens
Manually annotated by BRENDA team
Lagarou, A.; Mohd-Sarip, A.; Moshkin, Y.; Chalkley, G.; Bezstarosti, K.; Demmers, J.; Verrijzer, C.
dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing
Genes Dev.
22
2799-2810
2008
Drosophila melanogaster (Q9VHH9)
Manually annotated by BRENDA team
Cui, L.; Fan, Q.; Cui, L.; Miao, J.
Histone lysine methyltransferases and demethylases in Plasmodium falciparum
Int. J. Parasitol.
38
1083-1097
2008
Plasmodium falciparum
Manually annotated by BRENDA team
Polytarchou, C.; Pfau, R.; Hatziapostolou, M.; Tsichlis, P.
The JmjC domain histone demethylase Ndy1 regulates redox homeostasis and protects cells from oxidative stress
Mol. Cell. Biol.
28
7451-7464
2008
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Wallrath, L.; Elgin, S.
Stimulating conversations between HP1a and histone demethylase dKDM4A
Mol. Cell
32
601-602
2008
Drosophila melanogaster
Manually annotated by BRENDA team
Lin, C.H.; Li, B.; Swanson, S.; Zhang, Y.; Florens, L.; Washburn, M.P.; Abmayr, S.M.; Workman, J.L.
Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase
Mol. Cell
32
696-706
2008
Drosophila melanogaster, Drosophila melanogaster (Q9V333)
Manually annotated by BRENDA team
He, J.; Kallin, E.M.; Tsukada, Y.; Zhang, Y.
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b)
Nat. Struct. Mol. Biol.
15
1169-1175
2008
Mus musculus, Mus musculus (Q6P1G2)
Manually annotated by BRENDA team
Lan, F.; Shi, Y.
Epigenetic regulation: methylation of histone and non-histone proteins
Sci. China C Life Sci.
52
311-322
2009
Drosophila melanogaster
Manually annotated by BRENDA team
Chang, Y.; Wu, J.; Tong, X.J.; Zhou, J.Q.; Ding, J.
Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism
Biochem. J.
433
295-302
2010
Saccharomyces cerevisiae (P39956)
Manually annotated by BRENDA team
Strobl-Mazzulla, P.H.; Sauka-Spengler, T.; Bronner-Fraser, M.
Histone demethylase JmjD2A regulates neural crest specification
Dev. Cell
19
460-468
2010
Gallus gallus
Manually annotated by BRENDA team
Peng, Y.B.; Fan, B.; Han, X.L.; Xu, X.W.; Rothschild, M.F.; Yerle, M.; Liu, B.
Molecular characterization of the porcine JHDM1A gene associated with average daily gain: evaluation its role in skeletal muscle development and growth
Mol. Biol. Rep.
38
4697-4704
2011
Sus scrofa
Manually annotated by BRENDA team
He, J.; Nguyen, A.T.; Zhang, Y.
KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia
Blood
117
3869-3880
2011
Homo sapiens
Manually annotated by BRENDA team
Black, J.C.; Manning, A.L.; Van Rechem, C.; Kim, J.; Ladd, B.; Cho, J.; Pineda, C.M.; Murphy, N.; Daniels, D.L.; Montagna, C.; Lewis, P.W.; Glass, K.; Allis, C.D.; Dyson, N.J.; Getz, G.; Whetstine, J.R.
KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors
Cell
154
541-555
2013
Homo sapiens
Manually annotated by BRENDA team
Crona, F.; Dahlberg, O.; Lundberg, L.E.; Larsson, J.; Mannervik, M.
Gene regulation by the lysine demethylase KDM4A in Drosophila
Dev. Biol.
373
453-463
2013
Drosophila melanogaster
Manually annotated by BRENDA team
Ishimura, A.; Minehata, K.; Terashima, M.; Kondoh, G.; Hara, T.; Suzuki, T.
Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression
Development
139
749-759
2012
Mus musculus
Manually annotated by BRENDA team
Hillringhaus, L.; Yue, W.W.; Rose, N.R.; Ng, S.S.; Gileadi, C.; Loenarz, C.; Bello, S.H.; Bray, J.E.; Schofield, C.J.; Oppermann, U.
Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family
J. Biol. Chem.
286
41616-41625
2011
Homo sapiens, Homo sapiens (O75164), Homo sapiens (Q9H3R0)
Manually annotated by BRENDA team
Del Rizzo, P.A.; Krishnan, S.; Trievel, R.C.
Crystal structure and functional analysis of JMJD5 indicate an alternate specificity and function
Mol. Cell. Biol.
32
4044-4052
2012
Homo sapiens, Homo sapiens (Q8N371)
Manually annotated by BRENDA team
Liang, C.Y.; Hsu, P.H.; Chou, D.F.; Pan, C.Y.; Wang, L.C.; Huang, W.C.; Tsai, M.D.; Lo, W.S.
The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1
Nucleic Acids Res.
39
4151-4165
2011
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742
Manually annotated by BRENDA team
Pan, D.; Mao, C.; Zou, T.; Yao, A.Y.; Cooper, M.P.; Boyartchuk, V.; Wang, Y.X.
The histone demethylase Jhdm1a regulates hepatic gluconeogenesis
PLoS Genet.
8
e1002761
2012
Homo sapiens, Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Lin, C.H.; Paulson, A.; Abmayr, S.M.; Workman, J.L.
HP1a targets the Drosophila KDM4A demethylase to a subset of heterochromatic genes to regulate H3K36me3 levels
PLoS ONE
7
e39758
2012
Drosophila melanogaster
Manually annotated by BRENDA team
Fnu, S.; Williamson, E.; De Haro, L.; Brenneman, M.; Wray, J.; Shaheen, M.; Radhakrishnan, K.; Lee, S.; Nickoloff, J.; Hromas, R.
Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining
Proc. Natl. Acad. Sci. USA
108
540-545
2011
Homo sapiens
Manually annotated by BRENDA team
Hancock, R.L.; Masson, N.; Dunne, K.; Flashman, E.; Kawamura, A.
The activity of JmjC histone lysine demethylase KDM4A is highly sensitive to oxygen concentrations
ACS Chem. Biol.
12
1011-1019
2017
Homo sapiens (O75164)
Manually annotated by BRENDA team
Ryu, H.; Ahn, S.
Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic ribosomal DNA condensation
BMC Biol.
12
75
2014
Saccharomyces cerevisiae (P39956), Saccharomyces cerevisiae (P40034), Saccharomyces cerevisiae (Q03833)
Manually annotated by BRENDA team
Morera, L.; Roatsch, M.; Fuerst, M.C.; Hoffmann, I.; Senger, J.; Hau, M.; Franz, H.; Schuele, R.; Heinrich, M.R.; Jung, M.
4-biphenylalanine- and 3-phenyltyrosine-derived hydroxamic acids as inhibitors of the JumonjiC-domain-containing histone demethylase KDM4A
ChemMedChem
11
2063-2083
2016
Homo sapiens, Homo sapiens (O75164)
Manually annotated by BRENDA team
Pedersen, M.T.; Kooistra, S.M.; Radzisheuskaya, A.; Laugesen, A.; Johansen, J.V.; Hayward, D.G.; Nilsson, J.; Agger, K.; Helin, K.
Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development
EMBO J.
35
1550-1564
2016
Mus musculus, Mus musculus (Q8BW72), Mus musculus (Q8VCD7), Mus musculus C57BL/6 (Q8BW72), Mus musculus C57BL/6 (Q8VCD7)
Manually annotated by BRENDA team
Gacek-Matthews, A.; Noble, L.M.; Gruber, C.; Berger, H.; Sulyok, M.; Marcos, A.T.; Strauss, J.; Andrianopoulos, A.
KdmA, a histone H3 demethylase with bipartite function, differentially regulates primary and secondary metabolism in Aspergillus nidulans
Mol. Microbiol.
96
839-860
2015
Aspergillus nidulans, Aspergillus nidulans (Q5AW75), Aspergillus nidulans WIM126 (Q5AW75)
Manually annotated by BRENDA team
Kupershmit, I.; Khoury-Haddad, H.; Awwad, S.W.; Guttmann-Raviv, N.; Ayoub, N.
KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis
Nucleic Acids Res.
42
6168-6182
2014
Homo sapiens, Homo sapiens (O75164), Homo sapiens (O94953), Homo sapiens (Q6B0I6), Homo sapiens (Q9H3R0)
Manually annotated by BRENDA team
An, J.; Xu, J.; Li, J.; Jia, S.; Li, X.; Lu, Y.; Yang, Y.; Lin, Z.; Xin, X.; Wu, M.; Zheng, Q.; Pu, H.; Gui, X.; Li, T.; Lu, D.
HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372
Oncotarget
8
49093-49109
2017
Homo sapiens (O75164)
Manually annotated by BRENDA team