1.14.11.27: [histone-H3]-lysine-36 demethylase

This is an abbreviated version, for detailed information about [histone-H3]-lysine-36 demethylase, go to the full flat file.

Reaction

protein N6,N6-dimethyl-L-lysine
+
2-oxoglutarate
+
O2
=
protein N6-methyl-L-lysine
+
succinate
+
formaldehyde
+
CO2

Synonyms

AN1060, CG33182, CG33185, dJMJD2(1), dJMJD2(1)/CG15835, dJMJD2(2), dJMJD2(2)/CG33182, dKDM2, dKDM4A, dRAF, GASC1, Gis1, H3-K36 demethylase, H3-K36-specific demethylase, H3K36 demethylase, H3K36 histone demethylase, H3K36me2 demethylase, H3K36me2 histone demethylase, H3K36me2-specific demethylase, H3K9/36me3 lysine demethylase, H3K9/H3K36 histone demethylase, histone demethylase, histone demethylase JmjD2A, histone H3 demethylase, histone H3 lysine 36 demethylase, histone H3 lysine 36 dimethyl–specific demethylase, histone H3K36 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone-lysine(H3-K36) demethylase, histoneH3 demethylase, Jhd1, JHDM1A, Jhdm1b/Kdm2b, JmjC demethylase, JmjC domain histone demethylase, JmjC domain lysine demethylase, JmjC domain-containing histone demethylase 1, JmjC domain-containing histone demethylase 1A, JmjC domain-containing histone demethylation protein 3A, JmjC domain-containing histone demethylation protein 3b, JmjC histone lysine demethylase, JmjC protein, JmjC+N, JmjC+N histone demethylase, JMJD2, Jmjd2 demethylase, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD5, JumonjiC demethylase, KDM2B, KDM2b/JHDM1b, KDM4, KDM4A, KDM4A demethylase, KDM4A/JMJD2A, KDM4B, Kdm4c, KDM4D, KDM8, KdmA, lysine demethylase, More, Ndy1, PfJmjC1, Rph1, Rph1/KDM4, scJHDM1, [histone-H3]-lysine-36 demethylase 1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.27 [histone-H3]-lysine-36 demethylase

Substrates Products

Substrates Products on EC 1.14.11.27 - [histone-H3]-lysine-36 demethylase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATKAARK(me3)-SAPATGGVKKPHRYRPG-GK(biotin) + 2-oxoglutarate + O2
ATKAARKSAPATGGVKKPHRYRPG-GK(biotin) + succinate + formaldehyde + CO2
show the reaction diagram
-
usage of immunodetection for assay quantification
-
-
?
dimethyl-histone 3 L-lysine 36 + 2-oxoglutarate + O2
methyl-histone 3 L-lysine 36 + succinate + formaldehyde + CO2
show the reaction diagram
histone H3 N6,N6,N6-trimethyl-L-lysine26 + 2-oxoglutarate + O2
histone H3 N6,N6-dimethyl-L-lysine26 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
?
histone H3 N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
histone H3 N6,N6-dimethyl-L-lysine26 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
?
histone H3 N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
histone H3 N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
show the reaction diagram
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
?
histone H3 N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
histone H3 N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
show the reaction diagram
histone H3 N6-methyl-L-lysine36 + 2-oxoglutarate + O2
histone H3 L-lysine36 + succinate + formaldehyde + CO2
show the reaction diagram
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
show the reaction diagram
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
show the reaction diagram
protein 6-N,6-N-dimethyl-L-lysine + 2-oxoglutarate + O2
protein 6-N-methyl-L-lysine + succinate + formaldehyde + CO2
show the reaction diagram
-
specifically demethylates Lys36 of histone H3
-
-
?
protein 6-N-methyl-L-lysine + 2-oxoglutarate + O2
protein L-lysine + succinate + formaldehyde + CO2
show the reaction diagram
-
specifically demethylates Lys36 of histone H3
-
-
?
protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2
protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2
show the reaction diagram
protein N6,N6-dimethyl-L-lysine + 2 2-oxoglutarate + 2 O2
protein L-lysine + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
-
-
-
-
?
protein N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2
protein N6-methyl-L-lysine + succinate + formaldehyde + CO2
show the reaction diagram
-
specifically demethylates Lys36 of histone H3
-
-
?
protein N6-methyl-L-lysine + 2-oxoglutarate + O2
protein L-lysine + succinate + formaldehyde + CO2
show the reaction diagram
-
specifically demethylates Lys36 of histone H3
-
-
?
trimethyl-histone 3 L-lysine 36 + 2-oxoglutarate + O2
dimethyl-histone 3 L-lysine 36 + ?
show the reaction diagram
-
-
-
?
trimethyl-histone 3 L-lysine 36 + 2-oxoglutarate + O2
dimethyl-histone 3 L-lysine 36 + succinate + formaldehyde + CO2
show the reaction diagram
-
enzyme Rph1 is specific for di- and trimethyl-histone 3 L-lysine36
-
-
?
trimethyl-histone 3 L-lysine 36 + alpha-ketoglutarate + O2
dimethyl-histone 3 L-lysine 36 + ?
show the reaction diagram
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
[histone H3]-L-lysine36 + succinate + formaldehyde + CO2
show the reaction diagram
[histone H3]-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
[histone H3]-L-lysine36 + succinate + formaldehyde + CO2
show the reaction diagram
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
[histone H3]-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
additional information
?
-