1.14.11.27: [histone H3]-dimethyl-L-lysine36 demethylase

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For detailed information about [histone H3]-dimethyl-L-lysine36 demethylase, go to the full flat file.

Reaction

Synonyms

dKDM2, dKDM4A, dRAF, GASC1, H3-K36 demethylase, H3-K36-specific demethylase, H3K36 demethylase, H3K36me2 demethylase, H3K36me2 histone demethylase, H3K36me2-specific demethylase, histone H3 lysine 36 demethylase, histone H3 lysine 36 dimethyl�specific demethylase, histone-lysine(H3-K36) demethylase, Jhd1, JHDM1A, Jhdm1b/Kdm2b, JmjC domain histone demethylase, JmjC domain-containing histone demethylase 1, JmjC domain-containing histone demethylase 1A, JmjC domain-containing histone demethylation protein 1, JMJD2, JMJD2A, JMJD5, JMJD7, Kdm2a, KDM2B, KDM2b/JHDM1b, KDM4, KDM4A, KDM4B, Kdm4c, KDM4D, KDM8, lysine demethylase, More, Ndy1, PfJmjC1, PfSET1, scJHDM1, SET1, [histone-H3]-lysine-36 demethylase 1

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.27 [histone H3]-dimethyl-L-lysine36 demethylase

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4	Activating Compound
1348	AA Sequence
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1	CAS Registry Number
17	Cloned(Commentary)
1	Crystallization (Commentary)
1894	Disease/ Diagnostics
2	Expression
45	General Information
8	Localization
4	Metals/Ions
2	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
94	Organism
113	PDB ID
1	Posttranslational Modification
24	Protein Variants
4	Purification (Commentary)
3	Reaction
30	Reference
28	Source Tissue
52	Substrates and Products (Substrate)
4	Subunits
77	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.14.11.27 - [histone H3]-dimethyl-L-lysine36 demethylase

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SYSTEMATIC NAME

IUBMB Comments

[histone H3]-N6,N6-dimethyl-L-lysine36,2-oxoglutarate:oxygen oxidoreductase

Requires iron(II). Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys36. Lysine residues exist in three methylation states (mono-, di- and trimethylated). The enzyme preferentially demethylates the dimethyl form of Lys36 (K36me2), which is its natural substrate, to form the monomethylated and unmethylated forms of Lys36. It can also demethylate monomethylated (but not the trimethylated) Lys36. cf. EC 1.14.11.69, [histone H3]-trimethyl-L-lysine36 demethylase.