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1.14.11.28: proline 3-hydroxylase

This is an abbreviated version!
For detailed information about proline 3-hydroxylase, go to the full flat file.

Word Map on EC 1.14.11.28

Reaction

L-proline
+
2-oxoglutarate
+
O2
=
cis-3-hydroxy-L-proline
+
succinate
+
CO2

Synonyms

C-P3H, C-P4H, collagen prolyl hydroxylases 3, collagen prolyl hydroxylases 4, L-proline-3-hydroxylase, Leprel1, Leprel2, P-3-H, P3H, P3H1, P3H2, P3H3, proline 3-hydroxylase, proline 3-hydroxylase type I, proline 3-hydroxylase type II, prolyl 3-hydrolase, prolyl 3-hydroxylase 2

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.28 proline 3-hydroxylase

Specific Activity

Specific Activity on EC 1.14.11.28 - proline 3-hydroxylase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00119
-
5 mM 2-oxoglutarate, 1 mM ferrous sulfate, 5 mM L-ascorbic acid, 100 mM TES pH 7.5, 30°C
additional information
-
recombinant biotransformation of L-proline to cis-3-hydroxy-L-proline in Escherichia coli cells transformed with a synthetic P3H gene, overview