1.14.11.29: hypoxia-inducible factor-proline dioxygenase

This is an abbreviated version, for detailed information about hypoxia-inducible factor-proline dioxygenase, go to the full flat file.

Reaction

hypoxia-inducible factor-L-proline
+
2-oxoglutarate
 +
O2
=
hypoxia-inducible factor-trans-4-hydroxy-L-proline
 +
succinate
 +
CO2

Synonyms

factor inhibiting HIF, FIH, HIF hydroxylase, HIF prolyl, HIF prolyl hydroxylase, HIF-1alpha PHD3, HIF-1alpha prolyl hydroxylase 3, HIF-alpha prolyl-hydroxylase, HIF-P4H-1, HIF-P4H-2, HIF-P4H-3, HIF-PH, HIF-prolyl hydroxylase domain 2, HIF-prolyl hydroxylase-2, HPH-1, HPH-2, HPH-3, PHD, PHD1, PHD2, PHD3, proline hydroxylase domain 2, prolyl hydroxylase, prolyl hydroxylase domain, prolyl hydroxylase-2

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.29 hypoxia-inducible factor-proline dioxygenase