1.14.11.3: pyrimidine-deoxynucleoside 2'-dioxygenase

This is an abbreviated version, for detailed information about pyrimidine-deoxynucleoside 2'-dioxygenase, go to the full flat file.

Reaction

2'-deoxyuridine
+
2-oxoglutarate
+
O2
=
uridine
+
succinate
+
CO2

Synonyms

deoxyuridine 2'-dioxygenase, deoxyuridine 2'-hydroxylase, JBP1, JBP2, pyrimidine deoxyribonucleoside 2'-hydroxylase, thymidine 2'-dioxygenase, thymidine 2'-hydroxylase, thymidine 2-oxoglutarate dioxygenase, thymidine dioxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.3 pyrimidine-deoxynucleoside 2'-dioxygenase

Inhibitors

Inhibitors on EC 1.14.11.3 - pyrimidine-deoxynucleoside 2'-dioxygenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
at 0.02 mM complete inhibition
2,4-pyridinedicarboxylic acid
2-ketoadipate
-
38% inhibition at 2.5 mM
2-ketopimelate
-
26% inhibition at 2.5 mM
3-ketoadipate
-
50% inhibition at 2.5 mM
3-oxoglutarate
-
27% inhibition at 2.5 mM
Co2+
-
95% inhibition at 0.25 mM
Cu2+
-
95% inhibition at 0.25 mM
Diglycolate
-
18% inhibition at 2.5 mM
dimethyloxoglycine
glutamate
-
20% inhibition at 2.5 mM
iminodiacetate
-
28% inhibition at 2.5 mM
Mn2+
-
60% inhibition at 0.25 mM
N2
-
complete inhibition by exclusion of oxygen
Ni2+
-
95% inhibition at 0.25 mM
Thiodiglycolate
-
24% inhibition at 2.5 mM
Zn2+
-
95% inhibition at 0.25 mM