1.14.11.3: pyrimidine-deoxynucleoside 2'-dioxygenase

This is an abbreviated version, for detailed information about pyrimidine-deoxynucleoside 2'-dioxygenase, go to the full flat file.

Reaction

2'-deoxyuridine
+
2-oxoglutarate
+
O2
=
uridine
+
succinate
+
CO2

Synonyms

deoxyuridine 2'-dioxygenase, deoxyuridine 2'-hydroxylase, JBP1, JBP2, pyrimidine deoxyribonucleoside 2'-hydroxylase, thymidine 2'-dioxygenase, thymidine 2'-hydroxylase, thymidine 2-oxoglutarate dioxygenase, thymidine dioxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.3 pyrimidine-deoxynucleoside 2'-dioxygenase

KM Value

KM Value on EC 1.14.11.3 - pyrimidine-deoxynucleoside 2'-dioxygenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.3
2-oxoglutarate
-
-
0.15
5-bromodeoxyuridine
-
-
0.29
5-Hydroxymethyldeoxyuridine
-
-
0.29
6-Azathymidine
-
-
0.19
deoxyuridine
-
-
0.45
Fe2+
-
at pH 7.2 in 50 mM phosphate buffer
0.09
thymidine
-
-
0.07
thymidylate
-
-