1.14.11.30: hypoxia-inducible factor-asparagine dioxygenase

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Word Map on EC 1.14.11.30

Reaction

hypoxia-inducible factor-L-asparagine
+
2-oxoglutarate
+
O2
=
hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine
+
succinate
+
CO2

Synonyms

asparaginyl hydroxylase, asparaginyl-hydroxylase, factor inhibiting HIF, factor inhibiting HIF-1, factor inhibiting hypoxia inducible factor-1alpha, factor-inhibiting HIF, factor-inhibiting hypoxia-inducible factor, FIH, FIH hydroxylase, HIF asparagine hydroxylase, HIF asparaginyl hydroxylase, HIF hydroxylase, hypoxia-inducible factor asparagine hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.30 hypoxia-inducible factor-asparagine dioxygenase

Disease

Disease on EC 1.14.11.30 - hypoxia-inducible factor-asparagine dioxygenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Expression of erythropoietin and erythropoietin receptor in non-small cell lung carcinomas.
Carcinoma
Expression of erythropoietin and erythropoietin receptor in non-small cell lung carcinomas.
Carcinoma, Squamous Cell
Expression of erythropoietin and erythropoietin receptor in non-small cell lung carcinomas.
Colorectal Neoplasms
Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer.
Infections
Influenza A virus (H1N1) triggers a hypoxic response by stabilizing hypoxia-inducible factor-1? via inhibition of proteasome.
Neoplasms
Human placental hypoxia-inducible factor-1alpha expression correlates with clinical outcomes in chronic hypoxia in vivo.
Human Placental Hypoxia-Inducible Factor-1{alpha} Expression Correlates with Clinical Outcomes in Chronic Hypoxia in Vivo.
LDH-A influences hypoxia-inducible factor 1? (HIF1 ?) and is critical for growth of HT29 colon carcinoma cells in vivo.
NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells.
Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C.
The asparaginyl hydroxylase factor-inhibiting HIF is essential for tumor growth through suppression of the p53-p21 axis.
Pre-Eclampsia
[Clinical significance of hypoxia inducible factor-prolyl hydroxylase 1 and factor inhibiting hypoxia inducible factor-1 expression in placentas of women with severe pre-eclampsia]