1.14.11.30: hypoxia-inducible factor-asparagine dioxygenase

This is an abbreviated version!
For detailed information about hypoxia-inducible factor-asparagine dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.30

Reaction

hypoxia-inducible factor-L-asparagine
+
2-oxoglutarate
+
O2
=
hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine
+
succinate
+
CO2

Synonyms

asparaginyl hydroxylase, asparaginyl-hydroxylase, factor inhibiting HIF, factor inhibiting HIF-1, factor inhibiting hypoxia inducible factor-1alpha, factor-inhibiting HIF, factor-inhibiting hypoxia-inducible factor, FIH, FIH hydroxylase, HIF asparagine hydroxylase, HIF asparaginyl hydroxylase, HIF hydroxylase, hypoxia-inducible factor asparagine hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.30 hypoxia-inducible factor-asparagine dioxygenase

IC50 Value

IC50 Value on EC 1.14.11.30 - hypoxia-inducible factor-asparagine dioxygenase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.075
2,3-dihydroxypyridine
Homo sapiens
-
pH 7.0, 37°C
0.01
2-hydroxypyridine 1-oxide
Homo sapiens
-
pH 7.0, 37°C
1
3-cyano-6-methyl-2(H)-pyridinone
Homo sapiens
-
above, pH 7.0, 37°C
0.03
3-hydroxy-1,2-dimethyl-4(1H)-pyridinone
Homo sapiens
-
pH 7.0, 37°C
0.07
3-hydroxy-2-methyl-4-pyrone
Homo sapiens
-
above, pH 7.0, 37°C
0.05
4-methylcatechol
Homo sapiens
-
pH 7.0, 37°C
0.01
4-nitrocatechol
Homo sapiens
-
pH 7.0, 37°C
0.12
4-tert-butylcatechol
Homo sapiens
-
pH 7.0, 37°C
0.17
5-hydroxy-2-hydroxymethyl-4-pyrone
Homo sapiens
-
pH 7.0, 37°C
0.05
5-hydroxy-4-oxo-4H-pyran-2-carboxylic acid
Homo sapiens
-
pH 7.0, 37°C
0.01
Co2+
Homo sapiens
-
-
0.025
N-oxaloylglycine
Homo sapiens
-
-
0.01
Zn2+
Homo sapiens
-
-