1.14.11.30: hypoxia-inducible factor-asparagine dioxygenase
This is an abbreviated version!
For detailed information about hypoxia-inducible factor-asparagine dioxygenase, go to the full flat file.
Word Map on EC 1.14.11.30
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1.14.11.30
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prolyl
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hydroxylases
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transactivation
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oxygen-dependent
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ankyrin
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normoxia
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hippel-lindau
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oxygen-sensing
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hif-alpha
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prolyl-hydroxylase
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fih-mediated
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2og-dependent
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hypoxia-sensitive
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dimethyloxalylglycine
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2-oxoglutarate-dependent
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medicine
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drug development
- 1.14.11.30
-
prolyl
- hydroxylases
-
transactivation
-
oxygen-dependent
- ankyrin
-
normoxia
-
hippel-lindau
-
oxygen-sensing
-
hif-alpha
-
prolyl-hydroxylase
-
fih-mediated
-
2og-dependent
-
hypoxia-sensitive
- dimethyloxalylglycine
-
2-oxoglutarate-dependent
- medicine
- drug development
Reaction
Synonyms
asparaginyl hydroxylase, asparaginyl-hydroxylase, factor inhibiting HIF, factor inhibiting HIF-1, factor inhibiting hypoxia inducible factor-1alpha, factor-inhibiting HIF, factor-inhibiting hypoxia inducible factor, factor-inhibiting hypoxia-inducible factor, FIH, FIH hydroxylase, HIF asparagine hydroxylase, HIF asparaginyl hydroxylase, HIF hydroxylase, HIF1AN, hypoxia-inducible factor 1-alpha inhibitor, hypoxia-inducible factor asparagine hydroxylase
ECTree
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Systematic Name
Systematic Name on EC 1.14.11.30 - hypoxia-inducible factor-asparagine dioxygenase
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hypoxia-inducible factor-L-asparagine, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating)
Contains iron, and requires ascorbate. Catalyses hydroxylation of an asparagine in the C-terminal transcriptional activation domain of HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which reduces its interaction with the transcriptional coactivator protein p300. The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.