1.14.11.33: DNA oxidative demethylase
This is an abbreviated version!
For detailed information about DNA oxidative demethylase, go to the full flat file.
Word Map on EC 1.14.11.33
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1.14.11.33
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demethylation
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3-methylcytosine
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wobble
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1,n6-ethenoadenine
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alkbhs
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2-oxoglutarate-dependent
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dealkylation
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writer
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etheno
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epitranscriptomic
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5-methoxycarbonylmethyluridine
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n1-methyladenosine
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n6-methyladenine
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analysis
- 1.14.11.33
-
demethylation
- 3-methylcytosine
-
wobble
- 1,n6-ethenoadenine
-
alkbhs
-
2-oxoglutarate-dependent
-
dealkylation
-
writer
-
etheno
-
epitranscriptomic
-
5-methoxycarbonylmethyluridine
- n1-methyladenosine
- n6-methyladenine
- analysis
Reaction
Synonyms
1-methyladenine-DNA dioxygenase, ABH1, ABH2, ABH3, AlkB, AlkB homolog 1, ALKBH2, ALKBH3, ALKBH8, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, FTO
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 1.14.11.33 - DNA oxidative demethylase
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REACTION DIAGRAM
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
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-
-
?
DNA-1-methylguanine + 2-oxoglutarate + O2
DNA-guanine + formaldehyde + succinate + CO2
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-
-
-
?
DNA-2-methylguanosine + 2-oxoglutarate + O2
DNA-guanosine + formaldehyde + succinate + CO2
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-
-
?
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
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-
-
-
?
double-stranded DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
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major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
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-
?
double-stranded DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
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major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
methylated double-stranded bacteriophage lambda + 2-oxoglutarate + O2
double-stranded bacteriophage lambda + formaldehyde + succinate + CO2
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-
-
?
methylated RNA bacteriophage MS2 + 2-oxoglutarate + O2
RNA bacteriophage MS2 + formaldehyde + succinate + CO2
isoform ABH3 reactivates methylated single-stranded RNA bacteriophage MS2
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-
?
N6-methyladenine + 2-oxoglutarate + O2
adenine + formaldehyde + succinate + CO2
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via 6-hydroxymethyl adenine derivative
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-
?
single-stranded DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
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major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
single-stranded DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
DNA-adenine + formaldehyde + succinate + CO2
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-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
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-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
?
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
?
DNA-base + formaldehyde + succinate + CO2
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-
-
-
?
DNA-base-CH3 + 2-oxoglutarate + O2
DNA-base + formaldehyde + succinate + CO2
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-
-
?
DNA-base-CH3 + 2-oxoglutarate + O2
DNA-base + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-base-CH3 + 2-oxoglutarate + O2
DNA-base + formaldehyde + succinate + CO2
-
-
-
-
?
adenine + formaldehyde + succinate + CO2
-
-
-
-
?
N1-methyladenine + 2-oxoglutarate + O2
adenine + formaldehyde + succinate + CO2
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-
-
-
?
cytosine + formaldehyde + succinate + CO2
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-
-
-
?
N3-methylcytosine + 2-oxoglutarate + O2
cytosine + formaldehyde + succinate + CO2
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-
-
-
?
N3-methylcytosine + 2-oxoglutarate + O2
cytosine + formaldehyde + succinate + CO2
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-
-
-
?
RNA-base + formaldehyde + succinate + CO2
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-
-
-
?
RNA-base-CH3 + 2-oxoglutarate + O2
RNA-base + formaldehyde + succinate + CO2
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-
-
-
?
?
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-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
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-
?
additional information
?
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-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
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Agrobacterium tumefaciens C58 / ATCC 33970
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the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
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-
?
additional information
?
-
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the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
-
exocyclic carbons adjacent to the N6 of adenine are targets for oxidation by the Escherichia coli adaptive response protein AlkB
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-
?
additional information
?
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isoform ABH2 does not reactivate methylated RNA bacteriophage MS2 or methylated double-stranded bacteriophage lambda
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-
?
additional information
?
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isoform ABH2 does not reactivate methylated RNA bacteriophage MS2 or methylated double-stranded bacteriophage lambda
-
-
?
additional information
?
-
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?