1.14.11.4: procollagen-lysine 5-dioxygenase

This is an abbreviated version!
For detailed information about procollagen-lysine 5-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.4

Reaction

[procollagen]-L-lysine
+
2-oxoglutarate
+
O2
=
[procollagen]-(2S,5R)-5-hydroxy-L-lysine
+
succinate
+
CO2

Synonyms

2-oxoglutarate 5-dioxygenase 2, collagen lysine hydroxylase, Jmjd6, L230, LH, LH1, LH2, LH2 (long), LH2a, LH2b, LH3, lysine hydroxylase, lysine, 2-oxoglutarate 5-dioxygenase, lysine-2-oxoglutarate dioxygenase, lysyl 5S-hydroxylase, lysyl hydroxylase, lysyl hydroxylase 1, lysyl hydroxylase 2, lysyl hydroxylase 2 (long), lysyl hydroxylase 2a, lysyl hydroxylase 2b, lysyl hydroxylase 3, Lysyl hydroxylase-2b, lysyl-hydroxylase 1, lysylhydroxylase 2, lysylprotocollagen dioxygenase, More, oxygenase, protocollagen lysine, di-, peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase, peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase, PLOD, Plod1, PLOD2, Plod2a, Plod2b, PLOD2iso1, PLOD2iso2, PLOD3, procollagen lysyl hydroxylase 2, procollagen-lysine, procollagen-lysine 2-oxoglutarate 5-dioxygenase, procollagen-lysine, 2-oxoglutarate 5-dioxygenase, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2, protocollagen lysine hydroxylase, protocollagen lysyl hydroxylase, telopeptide lysyl hydroxylase, TLH

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.4 procollagen-lysine 5-dioxygenase

Molecular Weight

Molecular Weight on EC 1.14.11.4 - procollagen-lysine 5-dioxygenase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
115000
-
x * 70000 + x * 115000, SDS-PAGE
150000
-
gel filtration
180000
-
gel filtration, isoforms 1-3
200000
220000
-
gel filtration, peak 1
42000
x * 42000, recombinant His-tagged catalytic domain of JMJD6, residues 1-343
550000
-
gel filtration, peak 2
70000
-
x * 70000 + x * 115000, SDS-PAGE
80000
value about, Western blot
82380
2 * 82380, calculation from amino acid sequence, recombinant enzyme: isoform 3
84385
x * 84385, isozyme LH1, sequence calculation
84558
x * 84558, isozyme LH3, sequence calculation
85000
85063
x * 85063, isozyme LH2a, sequence calculation
86000
88000
2 * 88000 or 97000 SDS-PAGE, recombinant enzymes: isoform 2, possibly two forms are due to variation in the glycosylation of enzymes
89000
-
LH2, SDS-PAGE
97000
-
SDS-PAGE, V5-tagged LH2b