1.14.11.4: procollagen-lysine 5-dioxygenase

This is an abbreviated version!
For detailed information about procollagen-lysine 5-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.4

Reaction

[procollagen]-L-lysine
+
2-oxoglutarate
+
O2
=
[procollagen]-(2S,5R)-5-hydroxy-L-lysine
+
succinate
+
CO2

Synonyms

2-oxoglutarate 5-dioxygenase 2, collagen lysine hydroxylase, Jmjd6, L230, LH, LH1, LH2, LH2 (long), LH2a, LH2b, LH3, lysine hydroxylase, lysine, 2-oxoglutarate 5-dioxygenase, lysine-2-oxoglutarate dioxygenase, lysyl 5S-hydroxylase, lysyl hydroxylase, lysyl hydroxylase 1, lysyl hydroxylase 2, lysyl hydroxylase 2 (long), lysyl hydroxylase 2a, lysyl hydroxylase 2b, lysyl hydroxylase 3, Lysyl hydroxylase-2b, lysyl-hydroxylase 1, lysylhydroxylase 2, lysylprotocollagen dioxygenase, More, oxygenase, protocollagen lysine, di-, peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase, peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase, PLOD, Plod1, PLOD2, Plod2a, Plod2b, PLOD2iso1, PLOD2iso2, PLOD3, procollagen lysyl hydroxylase 2, procollagen-lysine, procollagen-lysine 2-oxoglutarate 5-dioxygenase, procollagen-lysine, 2-oxoglutarate 5-dioxygenase, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2, protocollagen lysine hydroxylase, protocollagen lysyl hydroxylase, telopeptide lysyl hydroxylase, TLH

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.4 procollagen-lysine 5-dioxygenase

Reference

Reference on EC 1.14.11.4 - procollagen-lysine 5-dioxygenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Majamaa, K.; Turpeenniemi-Hujanen, T.M.; Latipää, P.; Gunzler, V.; Hanauske-Abel, H.M.; Hassinen, I.E.; Kivirikko, K.I.
Differences between collagen hydroxylases and 2-oxoglutarate dehydrogenase in their inhibition by structural analogues of 2-oxoglutarate
Biochem. J.
229
127-133
1985
Gallus gallus
Manually annotated by BRENDA team
Kivirikko, K.I.; Myllylä, R.
The hydroxylation of prolyl and lysyl residues
Enzymol. Post- transl. Modif. Proteins (Freedman, R. B. , Hawkins, H. C. , eds. ) Academic Press, New York
1
53-104
1980
Gallus gallus
-
Manually annotated by BRENDA team
Kivirikko, K.I.; Myllylä, R.
Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes
Methods Enzymol.
82
245-304
1982
Gallus gallus, Homo sapiens
Manually annotated by BRENDA team
Puistola, U.
Catalytic properties of lysyl hydroxylase from cells synthesizing genetically different collagen types
Biochem. J.
201
215-219
1982
Gallus gallus, Homo sapiens
Manually annotated by BRENDA team
Royce, P.M.; Barnes, M.J.
Failure of highly purified lysyl hydroxylase to hydroxylate lysyl residues in the non-helical regions of collagen
Biochem. J.
230
475-480
1985
Gallus gallus
Manually annotated by BRENDA team
Puistola, U.; Turpeenniemi-Hujanen, T.M.; Myllylä, R.; Kivirikko, K.I.
Studies on the lysyl hydroxylase reaction. I. Initial velocity kinetics and related aspects
Biochim. Biophys. Acta
611
40-50
1980
Gallus gallus
Manually annotated by BRENDA team
Puistola, U.; Turpeenniemi-Hujanen, T.M.; Myllylä, R.; Kivirikko, K.I.
Studies on the lysyl hydroxylase reaction. II. Inhibition kinetics and the reaction mechanism
Biochim. Biophys. Acta
611
51-60
1980
Gallus gallus
Manually annotated by BRENDA team
Turpeenniemi-Hujanen, T.M.; Puistola, U.; Kivirikko, K.I.
Isolation of lysyl hydroxylase, an enzyme of collagen synthesis, from chick embryos as a homogeneous protein
Biochem. J.
189
247-253
1980
Gallus gallus
Manually annotated by BRENDA team
Miller, R.L.; Varner, H.H.
Purification and enzymatic properties of lysyl hydroxylase from fetal procine skin
Biochemistry
18
5928-5932
1979
Sus scrofa
-
Manually annotated by BRENDA team
Murray, J.C.; Cassell, R.H.; Pinnell, S.R.
Inhibition of lysyl hydroxylase by catechol analogs
Biochim. Biophys. Acta
481
63-70
1977
Gallus gallus
Manually annotated by BRENDA team
Ryhänen, L.
Lysyl hydroxylase. Further purification and characterization of the enzyme from chick embryos and chick embryo cartilage
Biochim. Biophys. Acta
438
71-89
1976
Gallus gallus
Manually annotated by BRENDA team
Kivirikko, K.I.; Shudo, K.; Sakakibara, S.; Prockop, D.J.
Studies on protocollagen lysine hydroxylase. Hydroxylation of synthetic peptides and the stoichiometric decarboxylation of alpha-ketoglutarate
Biochemistry
11
122-129
1972
Gallus gallus
Manually annotated by BRENDA team
Popenoe, E.A.; Aronson, R.B.
Partial purification and properties of collagen lysine hydroxylase from chick embryos
Biochim. Biophys. Acta
258
380-386
1972
Gallus gallus
Manually annotated by BRENDA team
Kivirikko, K.I.; Prockop, D.J.
Partial purification and characterization of protocollagen lysine hydroxylase from chick embryos
Biochim. Biophys. Acta
258
366-379
1972
Gallus gallus
Manually annotated by BRENDA team
Hausmann E.
Cofactor requirements for the enzymatic hydroxylation of lysine in a polypeptide precursor of collagen
Biochim. Biophys. Acta
133
591-593
1967
Gallus gallus
Manually annotated by BRENDA team
Kellokumpu, S.; Sormunen, R.; Heikkinen, J.; Myllyla, R.
Lysyl hydroxylase, a collagen processing enzyme, exemplifies a novel class of luminally-oriented peripheral membrane proteins in the endoplasmic reticulum
J. Biol. Chem.
269
30524-30529
1994
Homo sapiens
Manually annotated by BRENDA team
Valtavaara, M.; Papponen, H.; Pirttilae, A.M.; Hiltunen, K.; Helander, H.; Myllylae, R.
Cloning and characterization of a novel human lysyl hydroxylase isoform highly expressed in pancreas and muscle
J. Biol. Chem.
272
6831-6834
1997
Homo sapiens (O00469), Homo sapiens
Manually annotated by BRENDA team
Passoja, K.; Rautavuoma, K.; Ala-Kokko, L.; Kosonen, T.; Kivirikko, K.I.
Cloning and characterization of a third human lysyl hydroxylase isoform
Proc. Natl. Acad. Sci. USA
95
10482-10486
1998
Homo sapiens (O60568), Homo sapiens
Manually annotated by BRENDA team
Rautavuoma, K.; Takaluoma, K.; Passoja, K.; Pirskanen, A.; Kvist, A.P.; Kivirikko, K.I.; Myllyharju, J.
Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3: The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity
J. Biol. Chem.
277
23084-23091
2002
Homo sapiens
Manually annotated by BRENDA team
Wang, C.; Risteli, M.; Heikkinen, J.; Hussa, A.K.; Uitto, L.; Myllyla, R.
Identification of amino acids important for the catalytic activity of the collagen glucosyltransferase associated with the multifunctional lysyl hydroxylase 3 (LH3)
J. Biol. Chem.
277
18568-18573
2002
Caenorhabditis elegans
Manually annotated by BRENDA team
Samimi, A.; Last, J.A.
Mechanism of inhibition of lysyl hydroxylase activity by the organophosphates malathion and malaoxon
Toxicol. Appl. Pharmacol.
176
181-186
2001
Rattus norvegicus (Q63321)
Manually annotated by BRENDA team
Armstrong, L.C.; Last, J.A.
Rat lysyl hydroxylase: molecular cloning, mRNA distribution and expression in a baculovirus system
Biochim. Biophys. Acta
1264
93-102
1995
Gallus gallus, Homo sapiens, Rattus norvegicus (Q63321)
Manually annotated by BRENDA team
Mercer, D.K.; Nicol, P.F.; Kimbembe, C.; Robins, S.P.
Identification, expression, and tissue distribution of the three rat lysyl hydroxylase isoforms
Biochem. Biophys. Res. Commun.
307
803-809
2003
Rattus norvegicus, Rattus norvegicus (Q811A3)
Manually annotated by BRENDA team
Suokas, M.; Lampela, O.; Juffer, A.H.; Myllyla, R.; Kellokumpu, S.
Retrieval-independent localization of lysyl hydroxylase in the endoplasmic reticulum via a peptide fold in its iron-binding domain
Biochem. J.
370
913-920
2003
Homo sapiens
Manually annotated by BRENDA team
van der Slot, A.J.; Zuurmond, A.M.; Bardoel, A.F.; Wijmenga, C.; Pruijs, H.E.; Sillence, D.O.; Brinckmann, J.; Abraham, D.J.; Black, C.M.; Verzijl, N.; DeGroot, J.; Hanemaaijer, R.; TeKoppele, J.M.; Huizinga, T.W.; Bank, R.A.
Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis
J. Biol. Chem.
278
40967-40972
2003
Homo sapiens (O00469), Homo sapiens
Manually annotated by BRENDA team
Risteli, M.; Niemitalo, O.; Lankinen, H.; Juffer, A.H.; Myllyla, R.
Characterization of collagenous peptides bound to lysyl hydroxylase isoforms
J. Biol. Chem.
279
37535-37543
2004
Caenorhabditis elegans, Homo sapiens
Manually annotated by BRENDA team
Pornprasertsuk, S.; Duarte, W.R.; Mochida, Y.; Yamauchi, M.
Lysyl hydroxylase-2b directs collagen cross-linking pathways in MC3T3-E1 cells
J. Bone Miner. Res.
19
1349-1355
2004
Mus musculus
Manually annotated by BRENDA team
Walker, L.C.; Overstreet, M.A.; Siddiqui, A.; De Paepe, A.; Ceylaner, G.; Malfait, F.; Symoens, S.; Atsawasuwan, P.; Yamauchi, M.; Ceylaner, S.; Bank, R.A.; Yeowell, H.N.
A novel mutation in the lysyl hydroxylase 1 gene causes decreased lysyl hydroxylase activity in an Ehlers-Danlos VIA patient
J. Invest. Dermatol.
124
914-918
2005
Homo sapiens
Manually annotated by BRENDA team
Walker, L.C.; Overstreet, M.A.; Yeowell, H.N.
Tissue-specific expression and regulation of the alternatively-spliced forms of lysyl hydroxylase 2 (LH2) in human kidney cells and skin fibroblasts
Matrix Biol.
23
515-523
2005
Homo sapiens (O00469), Homo sapiens
Manually annotated by BRENDA team
Wu, J.; Reinhardt, D.P.; Batmunkh, C.; Lindenmaier, W.; Far, R.K.; Notbohm, H.; Hunzelmann, N.; Brinckmann, J.
Functional diversity of lysyl hydroxylase 2 in collagen synthesis of human dermal fibroblasts
Exp. Cell Res.
312
3485-3494
2006
Homo sapiens
Manually annotated by BRENDA team
Pornprasertsuk, S.; Duarte, W.R.; Mochida, Y.; Yamauchi, M.
Overexpression of lysyl hydroxylase-2b leads to defective collagen fibrillogenesis and matrix mineralization
J. Bone Miner. Res.
20
81-87
2005
Mus musculus
Manually annotated by BRENDA team
Ruotsalainen, H.; Sipilae, L.; Vapola, M.; Sormunen, R.; Salo, A.M.; Uitto, L.; Mercer, D.K.; Robins, S.P.; Risteli, M.; Aszodi, A.; Faessler, R.; Myllylae, R.
Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes
J. Cell Sci.
119
625-635
2006
Mus musculus
Manually annotated by BRENDA team
Salo, A.M.; Wang, C.; Sipilae, L.; Sormunen, R.; Vapola, M.; Kervinen, P.; Ruotsalainen, H.; Heikkinen, J.; Myllylae, R.
Lysyl hydroxylase 3 (LH3) modifies proteins in the extracellular space, a novel mechanism for matrix remodeling
J. Cell. Physiol.
207
644-653
2006
Mus musculus
Manually annotated by BRENDA team
Zuurmond, A.M.; van der Slot-Verhoeven, A.J.; van Dura, E.A.; De Groot, J.; Bank, R.A.
Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: implications for collagen cross-linking and treatment of fibrosis
Matrix Biol.
24
261-270
2005
Homo sapiens
Manually annotated by BRENDA team
Salo, A.M.; Sipilae, L.; Sormunen, R.; Ruotsalainen, H.; Vainio, S.; Myllylae, R.
The lysyl hydroxylase isoforms are widely expressed during mouse embryogenesis, but obtain tissue- and cell-specific patterns in the adult
Matrix Biol.
25
475-483
2006
Mus musculus
Manually annotated by BRENDA team
Schneider, V.A.; Granato, M.
Genomic structure and embryonic expression of zebrafish lysyl hydroxylase 1 and lysyl hydroxylase 2
Matrix Biol.
26
12-19
2007
Danio rerio (A0JMD1), Danio rerio (A4U7F8), Danio rerio (A4U7F9), Danio rerio
Manually annotated by BRENDA team
Takaluoma, K.; Lantto, J.; Myllyharju, J.
Lysyl hydroxylase 2 is a specific telopeptide hydroxylase, while all three isoenzymes hydroxylate collagenous sequences
Matrix Biol.
26
396-403
2007
Homo sapiens
Manually annotated by BRENDA team
Takaluoma, K.; Hyry, M.; Lantto, J.; Sormunen, R.; Bank, R.A.; Kivirikko, K.I.; Myllyharju, J.; Soininen, R.
Tissue-specific changes in the hydroxylysine content and cross-links of collagens and alterations in fibril morphology in lysyl hydroxylase 1 knock-out mice
J. Biol. Chem.
282
6588-6596
2007
Mus musculus (Q9R0E2)
Manually annotated by BRENDA team
Salo, A.M.; Cox, H.; Farndon, P.; Moss, C.; Grindulis, H.; Risteli, M.; Robins, S.P.; Myllylae, R.
A connective tissue disorder caused by mutations of the lysyl hydroxylase 3 gene
Am. J. Hum. Genet.
83
495-503
2008
Homo sapiens, Homo sapiens (O60568)
Manually annotated by BRENDA team
Nagaoka, H.; Mochida, Y.; Atsawasuwan, P.; Kaku, M.; Kondoh, T.; Yamauchi, M.
1,25(OH)2D3 regulates collagen quality in an osteoblastic cell culture system
Biochem. Biophys. Res. Commun.
377
674-678
2008
Mus musculus
Manually annotated by BRENDA team
Stein, H.; Wilensky, M.; Tsafrir, Y.; Rosenthal, M.; Amir, R.; Avraham, T.; Ofir, K.; Dgany, O.; Yayon, A.; Shoseyov, O.
Production of bioactive, post-translationally modified, heterotrimeric, human recombinant type-I collagen in transgenic tobacco
Biomacromolecules
10
2640-2645
2009
Homo sapiens
Manually annotated by BRENDA team
Risteli, M.; Ruotsalainen, H.; Salo, A.M.; Sormunen, R.; Sipilae, L.; Baker, N.L.; Lamande, S.R.; Vimpari-Kauppinen, L.; Myllylae, R.
Reduction of lysyl hydroxylase 3 causes deleterious changes in the deposition and organization of extracellular matrix
J. Biol. Chem.
284
28204-28211
2009
Homo sapiens, Homo sapiens (O60568)
Manually annotated by BRENDA team
Hyry, M.; Lantto, J.; Myllyharju, J.
Missense mutations that cause Bruck syndrome affect enzymatic activity, folding, and oligomerization of lysyl hydroxylase 2
J. Biol. Chem.
284
30917-30924
2009
Homo sapiens
Manually annotated by BRENDA team
Wang, C.; Kovanen, V.; Raudasoja, P.; Eskelinen, S.; Pospiech, H.; Myllylae, R.
The glycosyltransferase activities of lysyl hydroxylase 3 (LH3) in the extracellular space are important for cell growth and viability
J. Cell. Mol. Med.
13
508-521
2009
Homo sapiens (O60568)
Manually annotated by BRENDA team
Yeowell, H.N.; Walker, L.C.; Mauger, D.M.; Seth, P.; Garcia-Blanco, M.A.
TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2
J. Invest. Dermatol.
129
1402-1411
2009
Homo sapiens
Manually annotated by BRENDA team
Webby, C.J.; Wolf, A.; Gromak, N.; Dreger, M.; Kramer, H.; Kessler, B.; Nielsen, M.L.; Schmitz, C.; Butler, D.S.; Yates, J.R.; Delahunty, C.M.; Hahn, P.; Lengeling, A.; Mann, M.; Proudfoot, N.J.; Schofield, C.J.; Boettger, A.
Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing
Science
325
90-93
2009
Homo sapiens
Manually annotated by BRENDA team
Mantri, M.; Krojer, T.; Bagg, E.A.; Webby, C.J.; Butler, D.S.; Kochan, G.; Kavanagh, K.L.; Oppermann, U.; McDonough, M.A.; Schofield, C.J.
Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6
J. Mol. Biol.
401
211-222
2010
Homo sapiens (Q6NYC1)
Manually annotated by BRENDA team
Wang, C.; Ristiluoma, M.M.; Salo, A.M.; Eskelinen, S.; Myllylae, R.
Lysyl hydroxylase 3 is secreted from cells by two pathways
J. Cell. Physiol.
227
668-675
2012
Canis lupus familiaris, Homo sapiens (O60568), Canis lupus familiaris Madin-Darby
Manually annotated by BRENDA team
Remst, D.F.; Blaney Davidson, E.N.; Vitters, E.L.; Bank, R.A.; van den Berg, W.B.; van der Kraan, P.M.
TGF-beta induces lysyl hydroxylase 2b in human synovial osteoarthritic fibroblasts through ALK5 signaling
Cell Tissue Res.
355
163-171
2013
Homo sapiens
Manually annotated by BRENDA team
Tsukamoto, H.; Yokoyama, Y.; Suzuki, T.; Mizuta, S.; Yoshinaka, R.; Akahane, Y.
Cloning and expression of cDNA encoding lysyl hydroxylase 1, 2 and 3 in tiger puffer Takifugu rubripes
Comp. Biochem. Physiol. B
166
123-132
2013
Takifugu rubripes (A5A6S1), Takifugu rubripes (A5A6S2), Takifugu rubripes (A5A6S3), Takifugu rubripes
Manually annotated by BRENDA team
Bunt, S.; Denholm, B.; Skaer, H.
Characterisation of the Drosophila procollagen lysyl hydroxylase, dPlod
Gene Expr. Patterns
11
72-78
2011
Drosophila melanogaster
Manually annotated by BRENDA team
Luther, K.B.; Huelsmeier, A.J.; Schegg, B.; Deuber, S.A.; Raoult, D.; Hennet, T.
Mimivirus collagen is modified by bifunctional lysyl hydroxylase and glycosyltransferase enzyme
J. Biol. Chem.
286
43701-43709
2011
Acanthamoeba polyphaga Mimivirus, Acanthamoeba polyphaga Mimivirus L230
Manually annotated by BRENDA team
Sricholpech, M.; Perdivara, I.; Nagaoka, H.; Yokoyama, M.; Tomer, K.B.; Yamauchi, M.
Lysyl hydroxylase 3 glucosylates galactosylhydroxylysine residues in type I collagen in osteoblast culture
J. Biol. Chem.
286
8846-8856
2011
Mus musculus (Q9R0E1), Mus musculus, Mus musculus CRL-2593 (Q9R0E1)
Manually annotated by BRENDA team
Heikkinen, J.; Risteli, M.; Lampela, O.; Alavesa, P.; Karppinen, M.; Juffer, A.; Myllylae, R.
Dimerization of human lysyl hydroxylase 3 (LH3) is mediated by the amino acids 541-547
Matrix Biol.
30
27-33
2011
Homo sapiens
Manually annotated by BRENDA team
Mantri, M.; Webby, C.; Loik, N.; Hamed, R.; Nielsen, M.; McDonough, M.; McCullagh, J.; Boettger, A.; Schofield, C.; Wolf, A.
Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6
MedChemComm
3
80-85
2012
Homo sapiens
-
Manually annotated by BRENDA team
Gilkes, D.M.; Bajpai, S.; Wong, C.C.; Chaturvedi, P.; Hubbi, M.E.; Wirtz, D.; Semenza, G.L.
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
Mol. Cancer Res.
11
456-466
2013
Homo sapiens
Manually annotated by BRENDA team
Ruotsalainen, H.; Risteli, M.; Wang, C.; Wang, Y.; Karppinen, M.; Bergmann, U.; Kvist, A.P.; Pospiech, H.; Herzig, K.H.; Myllylae, R.
The activities of lysyl hydroxylase 3 (LH3) regulate the amount and oligomerization status of adiponectin
PLoS ONE
7
e50045
2012
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Guo, H.F.; Cho, E.J.; Devkota, A.K.; Chen, Y.; Russell, W.; Phillips, G.N.; Yamauchi, M.; Dalby, K.N.; Kurie, J.M.
A scalable lysyl hydroxylase 2 expression system and luciferase-based enzymatic activity assay
Arch. Biochem. Biophys.
618
45-51
2017
Homo sapiens (O00469), Homo sapiens
Manually annotated by BRENDA team
Dayer, C.; Stamenkovic, I.
Recruitment of matrix metalloproteinase-9 (MMP-9) to the fibroblast cell surface by lysyl hydroxylase 3 (LH3) triggers transforming growth factor-beta (TGF-beta) activation and fibroblast differentiation
J. Biol. Chem.
290
13763-13778
2015
Homo sapiens (O60568)
Manually annotated by BRENDA team
Gjaltema, R.A.; de Rond, S.; Rots, M.G.; Bank, R.A.
Procollagen lysyl hydroxylase 2 expression is regulated by an alternative downstream transforming growth factor beta-1 activation mechanism
J. Biol. Chem.
290
28465-28476
2015
Homo sapiens (O00469)
Manually annotated by BRENDA team
Kogan, N.M.; Melamed, E.; Wasserman, E.; Raphael, B.; Breuer, A.; Stok, K.S.; Sondergaard, R.; Escudero, A.V.; Baraghithy, S.; Attar-Namdar, M.; Friedlander-Barenboim, S.; Mathavan, N.; Isaksson, H.; Mechoulam, R.; Mueller, R.; Bajayo, A.; Gabet, Y.; Bab, I.
Cannabidiol, a major non-psychotropic cannabis constituent enhances fracture healing and stimulates lysyl hydroxylase activity in osteoblasts
J. Bone Miner. Res.
30
1905-1913
2015
Rattus norvegicus (Q5U367), Rattus norvegicus (Q63321), Rattus norvegicus (Q811A3)
Manually annotated by BRENDA team
Chen, Y.; Terajima, M.; Yang, Y.; Sun, L.; Ahn, Y.H.; Pankova, D.; Puperi, D.S.; Watanabe, T.; Kim, M.P.; Blackmon, S.H.; Rodriguez, J.; Liu, H.; Behrens, C.; Wistuba, I.I.; Minelli, R.; Scott, K.L.; Sanchez-Adams, J.; Guilak, F.; Pati, D.; Thilaganathan, N.; Burns, A.R.; Creighton, C.J.; Martinez, E.D.; Zal, T.; Allen, K.; Yamauchi, M.; Kurie, J.M.
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma
J. Clin. Invest.
125
1147-1162
2015
Homo sapiens (O00469), Homo sapiens, Mus musculus (Q9R0B9), Mus musculus
Manually annotated by BRENDA team
Zhang, L.; Li, M.M.; Corcoran, M.; Zhang, S.; Cooper, G.J.
Essential roles of insulin, AMPK signaling and lysyl and prolyl hydroxylases in the biosynthesis and multimerization of adiponectin
Mol. Cell. Endocrinol.
399
164-177
2015
Mus musculus (Q9R0B9), Mus musculus (Q9R0E1), Mus musculus (Q9R0E2)
Manually annotated by BRENDA team
Heard, M.E.; Besio, R.; Weis, M.; Rai, J.; Hudson, D.M.; Dimori, M.; Zimmerman, S.M.; Kamykowski, J.A.; Hogue, W.R.; Swain, F.L.; Burdine, M.S.; Mackintosh, S.G.; Tackett, A.J.; Suva, L.J.; Eyre, D.R.; Morello, R.
Sc65-null mice provide evidence for a novel endoplasmic reticulum complex regulating collagen lysyl hydroxylation
PLoS Genet.
12
e1006002
2016
Mus musculus (Q9R0E2), Mus musculus, Mus musculus 714 (Q9R0E2)
Manually annotated by BRENDA team
Risteli, M.; Ruotsalainen, H.; Bergmann, U.; Venkatraman Girija, U.; Wallis, R.; Myllylae, R.
Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin
PLoS ONE
9
e113498
2014
Mus musculus (Q9R0E1), Mus musculus, Mus musculus C57BL/6 (Q9R0E1)
Manually annotated by BRENDA team
Chen, Y.; Terajima, M.; Banerjee, P.; Guo, H.; Liu, X.; Yu, J.; Yamauchi, M.; Kurie, J.M.
FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch
Sci. Rep.
7
46021
2017
Mus musculus (Q9R0B9), Mus musculus
Manually annotated by BRENDA team
Neyazi, B.; Tanrikulu, L.; Wilkens, L.; Hartmann, C.; Stein, K.P.; Dumitru, C.A.; Sandalcioglu, I.E.
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 expression in brain arteriovenous malformations and its association with brain arteriovenous malformation size
World Neurosurg.
102
79-84
2017
Homo sapiens (O00469), Homo sapiens
Manually annotated by BRENDA team