1.14.11.4: procollagen-lysine 5-dioxygenase

This is an abbreviated version!
For detailed information about procollagen-lysine 5-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.4

Reaction

[procollagen]-L-lysine
+
2-oxoglutarate
+
O2
=
[procollagen]-(2S,5R)-5-hydroxy-L-lysine
+
succinate
+
CO2

Synonyms

2-oxoglutarate 5-dioxygenase 2, collagen lysine hydroxylase, Jmjd6, L230, LH, LH1, LH2, LH2 (long), LH2a, LH2b, LH3, lysine hydroxylase, lysine, 2-oxoglutarate 5-dioxygenase, lysine-2-oxoglutarate dioxygenase, lysyl 5S-hydroxylase, lysyl hydroxylase, lysyl hydroxylase 1, lysyl hydroxylase 2, lysyl hydroxylase 2 (long), lysyl hydroxylase 2a, lysyl hydroxylase 2b, lysyl hydroxylase 3, Lysyl hydroxylase-2b, lysyl-hydroxylase 1, lysylhydroxylase 2, lysylprotocollagen dioxygenase, More, oxygenase, protocollagen lysine, di-, peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase, peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase, PLOD, Plod1, PLOD2, Plod2a, Plod2b, PLOD2iso1, PLOD2iso2, PLOD3, procollagen lysyl hydroxylase 2, procollagen-lysine, procollagen-lysine 2-oxoglutarate 5-dioxygenase, procollagen-lysine, 2-oxoglutarate 5-dioxygenase, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2, protocollagen lysine hydroxylase, protocollagen lysyl hydroxylase, telopeptide lysyl hydroxylase, TLH

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.4 procollagen-lysine 5-dioxygenase

Source Tissue

Source Tissue on EC 1.14.11.4 - procollagen-lysine 5-dioxygenase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
p21-deficient (KC) and -replete (K) murine lung adenocarcinoma cells, increased LH2 enzyme activity
Manually annotated by BRENDA team
expression only of LH2long
Manually annotated by BRENDA team
stem marrow cell, no expression of isozymes LH3 and LH2b
Manually annotated by BRENDA team
expression only of LH2long
Manually annotated by BRENDA team
4 lung adenocarcinoma cell lines (KC1–KC4) from lung tumors in KC mice and 2 lung adenocarcinoma cell lines (K1 and K2) from Cdkn1aWT K-rasLA1 mice. Expression levels of the third gene of interest, LH2, are 10-30 times higher in the highly metastatic KC cells and include both LH2 isoforms, full-length (LH2b) and spliced at exon 13 (LH2a)
Manually annotated by BRENDA team
increased LH2 enzyme activity in lung carcinoma compared to healthy lung
Manually annotated by BRENDA team
additional information