1.14.11.51: DNA N6-methyladenine demethylase

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For detailed information about DNA N6-methyladenine demethylase, go to the full flat file.

Word Map on EC 1.14.11.51

Reaction

N6-methyladenine in DNA
+
2-oxoglutarate
+
O2
=
adenine in DNA
+
formaldehyde
+
succinate
+
CO2

Synonyms

6mA DNA demethylase, ALKBH1, DMAD, DNA 6mA demethylase, NMAD-1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.51 DNA N6-methyladenine demethylase

Systematic Name

Systematic Name on EC 1.14.11.51 - DNA N6-methyladenine demethylase

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SYSTEMATIC NAME
IUBMB Comments
DNA-N6-methyladenosine,2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming)
Contains iron(II). Catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons, which are specifically enriched on the human X chromosome.