1.14.11.53: mRNA N6-methyladenine demethylase

This is an abbreviated version!
For detailed information about mRNA N6-methyladenine demethylase, go to the full flat file.

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Synonyms

AlkB homolog 5, ALKBH10B, ALKBH5, ALKBH5 demethylase, ALKBH9B, alkylation repair homolog protein 5, fat mass and obesity-associated enzyme, fat mass and obesity-associated protein, FTO, m6A mRNA demethylase, m6A RNA demethylase, m6A-RNA demethylase, N6-methyladenosine demethylase, RNA N6-methyladenine demethylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.53 mRNA N6-methyladenine demethylase

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Results	in table
1918	AA Sequence
7	Application
10	Cloned(Commentary)
6	Crystallization (Commentary)
777	Disease/ Diagnostics
4	Expression
26	General Information
2	General Stability
11	IC50 Value
23	Inhibitors
10	kcat/KM [mM/s]
11	KM Value [mM]
8	Localization
8	Metals/Ions
2	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
45	Organism
14	PDB ID
6	pH Optimum
1	Posttranslational Modification
21	Protein Variants
12	Purification (Commentary)
1	Reaction
44	Reference
42	Source Tissue
53	Substrates and Products (Substrate)
3	Subunits
53	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
10	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.14.11.53 - mRNA N6-methyladenine demethylase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

N6-methyladenine in mRNA + 2-oxoglutarate + O2

adenine in mRNA + formaldehyde + succinate + CO2

8 entries

N6-methyladenine in NANOG mRNA + 2-oxoglutarate + O2

adenine in NANOG mRNA + formaldehyde + succinate + CO2

Homo sapiens

-

-

739559

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme binds preferentially to pre-mRNAs in intronic regions, in the proximity of alternatively spliced exons and poly(A) sites

743373

-

-

?

N6-methyladenine in mRNA + 2-oxoglutarate + O2

adenine in mRNA + formaldehyde + succinate + CO2

Danio rerio

Q08BA6

-

738237

-

-

?

N6-methyladenine in mRNA + 2-oxoglutarate + O2

adenine in mRNA + formaldehyde + succinate + CO2

Homo sapiens

-

-

737368, 737446, 738271, 738709, 738753, 739688, 742218, 742336, 743216, 743373, 743572, 743808

-

-

?

N6-methyladenine in mRNA + 2-oxoglutarate + O2

adenine in mRNA + formaldehyde + succinate + CO2

Homo sapiens

Q9C0B1

-

736100

-

-

?

N6-methyladenine in mRNA + 2-oxoglutarate + O2

adenine in mRNA + formaldehyde + succinate + CO2

Homo sapiens

Q6P6C2

-

739064, 739198

-

-

?

N6-methyladenine in mRNA + 2-oxoglutarate + O2

adenine in mRNA + formaldehyde + succinate + CO2

Homo sapiens

-

-

739198

-

-

?

N6-methyladenine in mRNA + 2-oxoglutarate + O2

adenine in mRNA + formaldehyde + succinate + CO2

Homo sapiens

Q9C0B1

m6A in nuclear RNA is the physiological substrate of the enzyme

739140

-

-

?

N6-methyladenine in mRNA + 2-oxoglutarate + O2

adenine in mRNA + formaldehyde + succinate + CO2

Homo sapiens

-

m6A modification preferentially appears after G in the conserved motif RRm6ACH (R is A/G and H is A/C/U)

738087

-

-

?

N6-methyladenine in mRNA + 2-oxoglutarate + O2

adenine in mRNA + formaldehyde + succinate + CO2

Mus musculus

Q3TSG4

-

739064

-

-

?