1.14.11.60: scopoletin 8-hydroxylase

This is an abbreviated version!
For detailed information about scopoletin 8-hydroxylase, go to the full flat file.

Reaction

scopoletin
+
2-oxoglutarate
+
O2
=
fraxetin
+
succinate
+
CO2

Synonyms

At3g12900, At3g12900 protein, S8H

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.60 scopoletin 8-hydroxylase

General Information

General Information on EC 1.14.11.60 - scopoletin 8-hydroxylase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
mutants defective in the expression of S8H show increased sensitivity to growth on pH 7.0 media supplemented with an immobile source of Fe and reduced secretion of fraxetin. Transgenic lines overexpressing S8H exhibit an opposite phenotype. Supplementing the media containing immobile Fe with fraxetin partially rescues the s8h mutants
metabolism
physiological function
-
the enzyme participates in Fe acquisition by mediating the biosynthesis of fraxetin (7,8-dihydroxy-6-methoxycoumarin), a coumarin derived from the scopoletin pathway. Fraxetin secretion is a decisive factor for calcicole-calcifuge behavior (i.e. the ability/inability to thrive on alkaline soils) of plants