1.14.11.63: peptidyl-lysine (3S)-dioxygenase

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For detailed information about peptidyl-lysine (3S)-dioxygenase, go to the full flat file.

Reaction

Synonyms

JmjC domain-containing protein 7, JMJD7, Jumonji domain-containing protein 7

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.63 peptidyl-lysine (3S)-dioxygenase

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Results	in table
4	AA Sequence
1	Application
1	Cloned(Commentary)
1	Crystallization (Commentary)
4	General Information
7	IC50 Value
7	Inhibitors
2	Localization
2	Natural Substrates/ Products (Substrates)
6	Organism
1	Protein Variants
1	Reaction
6	Reference
1	Source Tissue
6	Substrates and Products (Substrate)
9	Synonyms
1	Systematic Name

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Application on EC 1.14.11.63 - peptidyl-lysine (3S)-dioxygenase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

medicine

Homo sapiens

P0C870

in head and neck squamous cell carcinoma, a read-through fusion gene JMJD7-PLA2G4B is present, splicing neighboring JMJD7 and phospholipase A2, group IVB (PLA2G4B) genes together. Ablation of JMJD7-PLA2G4B significantly inhibits proliferation of head and neck squamous cell carcinoma cells by promoting G1 cell cycle arrest and increased starvation-induced cell death compared to JMJD7-only knockdown head and neck squamous cell carcinoma cells. JMJD7-PLA2G4B modulates phosphorylation of protein kinase B to promote head and neck squamous cell carcinoma cell survival. JMJD7-PLA2G4B also regulates an E3 ligase S-phase kinase-associated protein 2 to control the cell cycle progression from G1 phase to S phase by inhibiting cyclin-dependent kinase inhibitor 1 and 1B expression

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