1.14.11.67: [histone H3]-trimethyl-L-lysine4 demethylase

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Word Map on EC 1.14.11.67

1.14.11.67

chromatin

demethylases

trimethylation

polycomb

x-linked

pluripotency

ccrcc

methyltransferases

intellectual

self-renewal

corepressors

h3k4me2

chip-seq

x-inactivation

histone-modifying

corest

prc1

chromatin-modifying

lys4

nanog

k-specific

Reaction

a [histone H3]-N6,N6,N6-trimethyl-L-lysine4

+ 3 2-oxoglutarate + 3 O2 =

+ 3 succinate + 3 formaldehyde + 3 CO2

Synonyms

amine oxidase (flavin-containing) domain 1, AOF1, At2g34880, CG33182, CG33185, CG3654, dJARID2, dJARID2/CG3654, dJMJD2(1), dJMJD2(1)/CG15835, dJMJD2(2), dJMJD2(2)/CG33182, Fbxl10, GH09982, H3K4 demethylase, H3K4 demethylase lysine-specific demethylase 5A, H3K4 histone demethylase, H3K4me3 demethylase, H3K4me3 histone demethylase, H3K4me3-specific demethylase, H3K4me3/2 histone demethylase, H3K9 trimethyl demethylase, histone 3 lysine 4 demethylase, histone demethylase, histone H3 lysine 4 demethylase, histone H3 lysine-4 demethylase, histone H3-K4 demethylase, histone H3K4 demethylase, histone H3K4-specific demethylase, histone lysine demethylase, histone-H3K4-specific demethylase, Jarid1, Jarid1a, JARID1B, JARID1C, Jarid2, JaridB, Jhd2, Jhdm1b/Kdm2b, JMJ15, JMJ703, JmjC domain histone demethylase, JmjC domain-containing histone demethylation protein 3A, JmjC domain-containing histone demethylation protein 3b, JmjC+N, JmjC+N histone demethylase, JMJD2A, JMJD2A-tudor, JMJD2B, jumonji AT rich interactive domain 1B, jumonji AT-rich interactive domain 1B, Jumonji demethylase, KDM1, KDM1B, KDM2, KDM5, KDM5A, KDM5B, KDM5b/JARID1b, KDM5C, KDM5D, Lid, little imaginal discs, LSD1, lysine demethylase, lysine demethylase 5b, lysine demethylase 7, lysine-specific demethylase, lysine-specific demethylase 1, lysine-specific demethylase 5A, lysine-specific demethylase 5B, lysine-specific demethylase JMJ703, Lysine-specific demethylase SE14, More, Ndy1, Os03g0151300, PHD finger protein 8, PHF8, PKDM7B, PLU-1, PLU1, RB-binding protein 2, RBP2, RBR-2, retinoblastoma binding protein 2, SE14, SMCX, trimethylated lysine 4 of histone H3 demethylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.67 [histone H3]-trimethyl-L-lysine4 demethylase

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Results	in table
6	Activating Compound
5242	AA Sequence
2	Application
32	Cloned(Commentary)
2	Cofactor
6	Crystallization (Commentary)
2154	Disease/ Diagnostics
5	Expression
110	General Information
18	IC50 Value
98	Inhibitors
17	kcat/KM [mM/s]
22	KM Value [mM]
39	Localization
21	Metals/Ions
1	Molecular Weight [Da]
122	Natural Substrates/ Products (Substrates)
245	Organism
2	PDB ID
6	pH Optimum
52	Protein Variants
13	Purification (Commentary)
4	Reaction
74	Reference
110	Source Tissue
169	Substrates and Products (Substrate)
8	Subunits
210	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
20	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.14.11.67 - [histone H3]-trimethyl-L-lysine4 demethylase

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0.000073

(3-phenyl-1-(p-tolyl)-1H-pyrazol-4-yl)(4-(2-(pyrrolidin-1-yl) ethyl)piperazin-1-yl) methanone

Homo sapiens

Q9UGL1

pH 7.5, temperature not specified in the publication

764626

0.00022

(E)-2-((3-(4-(dimethylamino)but-2-enamido)-phenyl)(2-(piperidin-1-yl)ethoxy)methyl)thieno[3,2-b]pyridine-7-carboxylic acid

Homo sapiens

pH and temperature not specified in the publication

757397

0.000093

1-(2-methoxyphenyl)-N-(2-methyl-2-morpholinopropyl)-3-phenyl-1H-pyrazole-4-carboxamide

Homo sapiens

Q9UGL1

pH 7.5, temperature not specified in the publication

764626

0.000024

1-(4-methoxyphenyl)-N-(2-methyl-2-morpholinopropyl)-3-phenyl-1H-pyrazole-4-carboxamide

Homo sapiens

Q9UGL1

pH 7.5, temperature not specified in the publication

764626

0.000098

2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)-N-ethylisonicotinamide

Homo sapiens

P29375, P41229, Q9BY66, Q9UGL1

pH and temperature not specified in the publication

744646

0.00027

2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)-N-methylisonicotinamide

Homo sapiens

P29375, P41229, Q9BY66, Q9UGL1

pH and temperature not specified in the publication

744646

0.000019 - 0.000071

2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinamide

3 entries

0.000007

2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid

Homo sapiens

P29375, P41229, Q9BY66, Q9UGL1

pH and temperature not specified in the publication

744646

0.00032

2-((2-chlorophenyl)(2-(1-methylpyrrolidin-2-yl)-ethoxy)methyl)thieno[3,2-b]pyridine-7-carboxylic acid

Homo sapiens

pH and temperature not specified in the publication

757397

0.00049

2-((3-aminophenyl)(2-(piperidin-1-yl)ethoxy)methyl)thieno[3,2-b]-pyridine-7-carboxylic acid

Homo sapiens

pH and temperature not specified in the publication

757397

0.00098

2-(piperazin-1-ylmethyl)isonicotinic acid

Homo sapiens

P29375, P41229, Q9BY66, Q9UGL1

pH and temperature not specified in the publication

744646

0.083

3-((2-(pyridin-2-yl)-6-(4-(vinylsulfonyl)-1,4-diazepan-1-yl)pyrimidin-4-yl)amino)propanoic acid

Homo sapiens

pH and temperature not specified in the publication

757397

0.071

3-((6-(4-acryloyl-1,4-diazepan-1-yl)-2-(pyridin-2-yl)-pyrimidin-4-yl)amino)propanoic acid

Homo sapiens

pH and temperature not specified in the publication

757397

0.000048

ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate

Homo sapiens

P29375, P41229, Q9BY66, Q9UGL1

pH and temperature not specified in the publication

744646

K+

Arabidopsis thaliana

at pH 8.0 and 25°C

756031

0.11

N-[2-(pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)pyrimidin-4-yl]-beta-alanine

Homo sapiens

pH and temperature not specified in the publication

757397