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1.14.11.67: [histone H3]-trimethyl-L-lysine4 demethylase

This is an abbreviated version!
For detailed information about [histone H3]-trimethyl-L-lysine4 demethylase, go to the full flat file.

Word Map on EC 1.14.11.67

Reaction

a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
+ 3 2-oxoglutarate + 3 O2 =
a [histone H3]-L-lysine4
 + 3 succinate + 3 formaldehyde + 3 CO2

Synonyms

amine oxidase (flavin-containing) domain 1, AOF1, At2g34880, CG33182, CG33185, CG3654, dJARID2, dJARID2/CG3654, dJMJD2(1), dJMJD2(1)/CG15835, dJMJD2(2), dJMJD2(2)/CG33182, Fbxl10, GH09982, H3K4 demethylase, H3K4 demethylase lysine-specific demethylase 5A, H3K4 histone demethylase, H3K4me3 demethylase, H3K4me3 histone demethylase, H3K4me3-specific demethylase, H3K4me3/2 histone demethylase, H3K9 trimethyl demethylase, histone 3 lysine 4 demethylase, histone demethylase, histone H3 lysine 4 demethylase, histone H3 lysine-4 demethylase, histone H3-K4 demethylase, histone H3K4 demethylase, histone H3K4-specific demethylase, histone lysine demethylase, histone-H3K4-specific demethylase, Jarid1, Jarid1a, JARID1B, JARID1C, Jarid2, JaridB, Jhd2, Jhdm1b/Kdm2b, JMJ15, JMJ703, JmjC domain histone demethylase, JmjC domain-containing histone demethylation protein 3A, JmjC domain-containing histone demethylation protein 3b, JmjC+N, JmjC+N histone demethylase, JMJD2A, JMJD2A-tudor, JMJD2B, jumonji AT rich interactive domain 1B, jumonji AT-rich interactive domain 1B, Jumonji demethylase, KDM1, KDM1B, KDM2, KDM5, KDM5A, KDM5B, KDM5b/JARID1b, KDM5C, KDM5D, Lid, little imaginal discs, LSD1, lysine demethylase, lysine demethylase 5b, lysine demethylase 7, lysine-specific demethylase, lysine-specific demethylase 1, lysine-specific demethylase 5A, lysine-specific demethylase 5B, lysine-specific demethylase JMJ703, Lysine-specific demethylase SE14, More, Ndy1, Os03g0151300, PHD finger protein 8, PHF8, PKDM7B, PLU-1, PLU1, RB-binding protein 2, RBP2, RBR-2, retinoblastoma binding protein 2, SE14, SMCX, trimethylated lysine 4 of histone H3 demethylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.67 [histone H3]-trimethyl-L-lysine4 demethylase

Substrates Products

Substrates Products on EC 1.14.11.67 - [histone H3]-trimethyl-L-lysine4 demethylase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ARTK(me3)QTARKS + 2-oxoglutarate + O2
ARTK(me2)QTARKS + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
?
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
histone H3 N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
histone H3 L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
?
histone H3 N6-methyl-L-lysine4 + 2-oxoglutarate + O2
histone H3 L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
trimethyl-histone 3 L-lysine 36 + alpha-ketoglutarate + O2
dimethyl-histone 3 L-lysine 36 + ?
show the reaction diagram
-
-
-
?
[acetylated histone H3 21mer]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
[acetylated histone H3 21mer]-N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
-
?
[acetylated histone H3 21mer]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
[acetylated histone H3 21mer]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
-
?
[histone H3 N-terminal 13mer] N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3 N-terminal 13mer] N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
H3 residue Q5 is critical for substrate recognition by KDM5A
-
-
?
[histone H3 N-terminal 18mer mutant K14A/R17A/K18A] N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3 N-terminal 18mer mutant K14A/R17A/K18A] N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
H3 residue Q5 is critical for substrate recognition by KDM5A
-
-
?
[histone H3 N-terminal 18mer mutant K14ac/K18ac] N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3 N-terminal 18mer mutant K14ac/K18ac] N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
H3 residue Q5 is critical for substrate recognition by KDM5A
-
-
?
[histone H3 N-terminal 18mer] N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3 N-terminal 18mer] N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
H3 residue Q5 is critical for substrate recognition by KDM5A
-
-
?
[histone H3 N-terminal 21mer mutant K9A] N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3 N-terminal 21mer mutant K9A] N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
H3 residue Q5 is critical for substrate recognition by KDM5A
-
-
?
[histone H3 N-terminal 21mer mutant Q5A] N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3 N-terminal 21mer mutant Q5A] N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
H3 residue Q5 is critical for substrate recognition by KDM5A
-
-
?
[histone H3 N-terminal 21mer mutant R2A] N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3 N-terminal 21mer mutant R2A] N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
H3 residue Q5 is critical for substrate recognition by KDM5A
-
-
?
[histone H3 N-terminal 21mer mutant R8A] N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3 N-terminal 21mer mutant R8A] N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
H3 residue Q5 is critical for substrate recognition by KDM5A
-
-
?
[histone H3 N-terminal 21mer mutant T3A] N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3 N-terminal 21mer mutant T3A] N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
H3 residue Q5 is critical for substrate recognition by KDM5A
-
-
?
[histone H3 N-terminal 21mer mutant T6A] N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3 N-terminal 21mer mutant T6A] N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
H3 residue Q5 is critical for substrate recognition by KDM5A
-
-
?
[histone H3 N-terminal 21mer mutant T6S] N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3 N-terminal 21mer mutant T6S] N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
H3 residue Q5 is critical for substrate recognition by KDM5A
-
-
?
[histone H3 N-terminal 21mer mutant T6V] N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3 N-terminal 21mer mutant T6V] N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
H3 residue Q5 is critical for substrate recognition by KDM5A
-
-
?
[histone H3 N-terminal 21mer] N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3 N-terminal 21mer] N-terminal N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
H3 residue Q5 is critical for substrate recognition by KDM5A
-
-
?
[histone H3] N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3] N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
H3 residue Q5 is critical for substrate recognition by KDM5A
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 4 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 4 + succinate + formaldehyde + CO2
show the reaction diagram
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2
[histone H3]-N6-methyl-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
-
overall reaction
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 3 2-oxoglutarate + 3 O2
[histone H3]-L-lysine4 + 3 succinate + 3 formaldehyde + 3 CO2
show the reaction diagram
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2
[histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2
[histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2
[histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
[histone H3]-N6,N6-drimethyl-L-lysine 4 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine 4 + succinate + formaldehyde + CO2
show the reaction diagram
[histone H3]-N6-methyl-L-lysine 4 + 2-oxoglutarate + O2
[histone H3]-L-lysine 4 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
[histone-H3]-dimethyllysine4 + 2-oxoglutarate + O2
?
show the reaction diagram
[histone-H3]-tridimethyllysine4 + 2-oxoglutarate + O2
?
show the reaction diagram
-
RBP2 is a demethylase that specifically catalyzes demethylation. RBP2 displayes robust H3K4 demethylase activity against H3K4me3 and me2, resulting in 80%-90% demethylation of the modified substrate, but fails to catalyze removal of the me1 modification state. The enzyme is capable of processively demethylating the H3K4me3 and me2 modifications to the unmodified state
-
-
?
[histone-H3]-trimethyllysine4 + 2-oxoglutarate + O2
?
show the reaction diagram
additional information
?
-