Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.11.68: [histone H3]-trimethyl-L-lysine27 demethylase

This is an abbreviated version!
For detailed information about [histone H3]-trimethyl-L-lysine27 demethylase, go to the full flat file.

Wordmap for 1.14.11.68

Word Map on EC 1.14.11.68 Wordmap for 1.14.11.68

Reaction

Show molfile
a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
+ 2 2-oxoglutarate + 2 O2 =
Show molfile
a [histone H3]-N6-methyl-L-lysine27
+ 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

F18E9.5, histone demethylase, jmjd-3.1, JMJD3, KDM6A, Kdm6al, KDM6B, KDM6C, lysine-specific demethylase 6A, lysine-specific demethylase 6B, UTX, UTX1, UTY

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                EC 1.14.11.681.14.11.68 [histone H3]-trimethyl-L-lysine27 demethylase

Localization

Localization on EC 1.14.11.68 - [histone H3]-trimethyl-L-lysine27 demethylase

for references in articles please use BRENDA:EC1.14.11.68

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
embryonic fibroblasts display a dynamic nucleocytoplasmic shuttling of endogenous Jmjd3. Jmjd3 is localized both into the cytoplasm and the nucleus, and its nuclear export is dependent on exportin-1
Manually annotated by BRENDA team