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1.14.11.7: procollagen-proline 3-dioxygenase

This is an abbreviated version!
For detailed information about procollagen-proline 3-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.7

Reaction

[procollagen]-L-proline
+
2-oxoglutarate
+
O2
=
[procollagen]-trans-3-hydroxy-L-proline
+
succinate
+
CO2

Synonyms

LEPRE1, Leprel1, Leprel2, More, oxygenase, protocollagen proline 3-di-, P3H1, P3H2, P3H3, PHD3, proline,2-oxoglutarate 3-dioxygenase, prolyl 3-hydroxylase, prolyl 3-hydroxylase 1, prolyl 3-hydroxylase 2, prolyl 3-hydroxylase-2, prolyl hydroxylase, prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating, protocollagen proline 3-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.7 procollagen-proline 3-dioxygenase

Purification

Purification on EC 1.14.11.7 - procollagen-proline 3-dioxygenase

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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
most of the recombinant isoform P3H2 is insoluble. Coexpression of protein with the cartilage-associated protein CRTAP does not enhance solubility
native prolyl 3-hydroxylation complex from embrtyos by ultracentrifugation and gelatin affinity chromatography
partial
-