1.14.11.7: procollagen-proline 3-dioxygenase
This is an abbreviated version!
For detailed information about procollagen-proline 3-dioxygenase, go to the full flat file.
Word Map on EC 1.14.11.7
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1.14.11.7
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hypoxia-inducible
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fibrosis
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hydroxyproline
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factor-1
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endothelial
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hydroxylases
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hif-1alpha
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erythropoietin
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anemia
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domain-containing
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lysyl
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ascorbate
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oxygen-dependent
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normoxic
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hippel-lindau
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4-hydroxylase
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imperfecta
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osteogenesis
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dmog
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dimethyloxalylglycine
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bleomycin
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factor-1alpha
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oxygen-sensing
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angiogenic
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2-oxoglutarate-dependent
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hypoxia-responsive
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chick-embryo
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hif-dependent
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hydroxylysine
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hif-prolyl
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roxadustat
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o2-dependent
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bleomycin-induced
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ppib
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polycythemia
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fkbp10
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intratracheal
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3-hydroxylation
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3,4-dihydroxybenzoic
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prolyl-hydroxylase
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hepcidin
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oxygen-sensitive
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1.14.11.2
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hydroxyproline-rich
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col1a2
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serpinh1
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lindau
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l-mimosine
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erythropoiesis-stimulating
- 1.14.11.7
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hypoxia-inducible
- fibrosis
- hydroxyproline
- factor-1
- endothelial
- hydroxylases
- hif-1alpha
- erythropoietin
- anemia
-
domain-containing
-
lysyl
- ascorbate
-
oxygen-dependent
-
normoxic
-
hippel-lindau
-
4-hydroxylase
- imperfecta
-
osteogenesis
- dmog
- dimethyloxalylglycine
- bleomycin
- factor-1alpha
-
oxygen-sensing
-
angiogenic
-
2-oxoglutarate-dependent
-
hypoxia-responsive
-
chick-embryo
-
hif-dependent
- hydroxylysine
-
hif-prolyl
-
roxadustat
-
o2-dependent
-
bleomycin-induced
- ppib
- polycythemia
- fkbp10
-
intratracheal
-
3-hydroxylation
-
3,4-dihydroxybenzoic
-
prolyl-hydroxylase
- hepcidin
-
oxygen-sensitive
-
1.14.11.2
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hydroxyproline-rich
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col1a2
-
serpinh1
-
lindau
- l-mimosine
-
erythropoiesis-stimulating
Reaction
Synonyms
LEPRE1, Leprel1, Leprel2, More, oxygenase, protocollagen proline 3-di-, P3H1, P3H2, P3H3, PHD3, proline,2-oxoglutarate 3-dioxygenase, prolyl 3-hydroxylase, prolyl 3-hydroxylase 1, prolyl 3-hydroxylase 2, prolyl 3-hydroxylase-2, prolyl hydroxylase, prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating, protocollagen proline 3-hydroxylase
ECTree
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Substrates Products
Substrates Products on EC 1.14.11.7 - procollagen-proline 3-dioxygenase
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REACTION DIAGRAM
(Gly-L-Pro-L-4-hydroxyproline)5 + 2-oxoglutarate + O2
(Gly-trans-3-hydroxy-L-Pro-trans-4-hydrox-L-Pro)5 + succinate + CO2
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-
?
(L-Pro-trans-4-hydroxy-L-Pro-Gly)5 + 2-oxoglutarate + O2
(trans-3-hydroxy-L-Pro-trans-4-hydroxy-L-Pro-Gly)5 + succinate + CO2
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-
-
?
L-Leu-L-Asn-Gly-L-Leu-L-4Hyp-Gly-L-Pro-L-Ile-Gly-L-Pro-L-4Hyp-Gly-L-Pro-L-Arg-Gly-L-Arg-L-Thr-Gly-L-Asp-L-Ala-Gly + 2-oxoglutarate + O2
L-Leu-L-Asn-Gly-L-Leu-L-4Hyp-Gly-trans-3-hydroxy-L-Pro-L-Ile-Gly-L-Pro-L-4Hyp-Gly-trans-3-hydroxy-L-Pro-L-Arg-Gly-L-Arg-L-Thr-Gly-L-Asp-L-Ala-Gly + succinate + CO2
peptide corresponding to the only prolyl 3-hydroxylation site in the alpha1 chain of collagen I
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-
?
L-Pro-L-Thr-Gly-L-Pro-L-Arg-Gly-L-Phe-L-Pro-Gly-L-Pro-L-4-hydroxyproline-Gly-L-Pro-L-Asp-Gly-L-Leu-L-4-hydroxyproline-Gly-L-Ser-L-Met-Gly + 2-oxoglutarate + O2
? + succinate + CO2
peptide corresponding to a known prolyl 3-hydroxylation site in the alpha1 chain of collagen IV
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-
?
L-proline + 2-oxoglutarate + O2
trans 3-hydroxy-L-proline + succinate
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?
L-proline-[collagen] + O2
(S3)-hydroxy-L-proline-[collagen]
prolyl 3-hydroxylase 1 modifies a single proline residue in the alpha chains of type I, II, and III collagens to (3S)-hydroxyproline
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?
L-proline-[collagen] + O2
3-hydroxy-L-proline-[collagen]
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?
L-Ser-L-Lys-Gly-L-Glu-L-Gln-Gly-L-Phe-L-Met-Gly-L-Pro-L-4-hydroxyproline-Gly-L-Pro-L-Gln-Gly-L-Gln-L-4-hydroyproline-Gly-L-Leu-L-4-hydroxyproline-Gly + 2-oxoglutarate + O2
? + succinate + CO2
peptide corresponding to a known prolyl 3-hydroxylation site in the alpha1 chain of collagen IV
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-
?
procollagen L-proline + 2-oxoglutarate + O2
procollagen trans-3-hydroxy-L-proline + succinate + CO2
[procollagen]-L-proline + 2-oxoglutarate + O2
[procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
procollagen trans-3-hydroxy-L-proline + succinate + CO2
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the enzyme catalyzes the synthesis of 3-hydroxyproline in collagen by the hydroxylation of prolyl residues
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?
procollagen + 2-oxoglutarate + O2
procollagen trans-3-hydroxy-L-proline + succinate + CO2
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?
procollagen + 2-oxoglutarate + O2
procollagen trans-3-hydroxy-L-proline + succinate + CO2
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the enzyme catalyzes the synthesis of 3-hydroxyproline in collagen by the hydroxylation of prolyl residues
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?
procollagen trans-3-hydroxy-L-proline + succinate + CO2
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proline-labelled polypeptide substrate
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?
procollagen L-proline + 2-oxoglutarate + O2
procollagen trans-3-hydroxy-L-proline + succinate + CO2
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P3H1 catalyzes the 3-hydroxylation of specific proline residues in procollagen I
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-
?
procollagen L-proline + 2-oxoglutarate + O2
procollagen trans-3-hydroxy-L-proline + succinate + CO2
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chicken embryo tendon protocollagen and procollagen or cartilage protocollagen. The formation of 3-hydroxyproline is affected by chain length and the conformation of the substrate, in that longer polypeptide chains proved better substrates, while the native triple-helical conformation of protocollagen or procollagen completely prevents the reaction
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-
?
procollagen L-proline + 2-oxoglutarate + O2
procollagen trans-3-hydroxy-L-proline + succinate + CO2
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2,3-T-L-proline-labeled polypeptide substrate
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?
protocollagen containing 4-hydroxyproline + 2-oxoglutarate + O2
?
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?
[procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
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?
[procollagen]-L-proline + 2-oxoglutarate + O2
[procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
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?
[procollagen]-L-proline + 2-oxoglutarate + O2
[procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
prolyl 3-hydroxylation in lens capsule, prolyl 3-hydroxylation at Pro602 from alpha1(IV) and Pro197 from alpha2(IV). Pro707 site in alpha1(I) is a tissue-specific substrate unique to P3h2
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?
[procollagen]-L-proline + 2-oxoglutarate + O2
[procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
Residue alpha1(I) K930 is 98% hydroxylated and non-glycosylated in both genotypes and alpha1(I)K87 is 92% hydroxylated in wild-type and 93% in Lepre1H662A/H662A
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?
[procollagen]-L-proline + 2-oxoglutarate + O2
[procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
type IV collagen
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?
[procollagen]-L-proline + 2-oxoglutarate + O2
[procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
collagen from bovine tissue. 3-hydroxyproline occupancy in collagens from bovine and mouse tissues, overview
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?
?
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the P3H1-CRTAP-Cyp B complex does not stabilize the collagen triple helix, but does inhibit collgane fibril formation, overview
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?
additional information
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isoform P3H2 is responsible for the hydroxylation of collagen IV
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?
additional information
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isoform P3H2 is responsible for the hydroxylation of collagen IV
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additional information
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isoform P3H2 is responsible for the hydroxylation of collagen IV
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additional information
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the collagen prolyl 3-hydroxylation complex, comprised by cyclophilin B (PPIB), CRTAP and P3H1, catalyzes a specific posttranslational modification of types I, II, and V collagen, and may act as a general chaperone. Collagen 3-hydroxylation complex function, overview
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?
additional information
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P3H1 contains four tetratricopeptide repeats, which are important for protein-protein interactions, and a leucine zipper, L445TREGGPLLYEGISLTMNSKLL466, which is involved in protein dimerization
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?
additional information
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type IV collagen contains more prolyl 3-hydroxylation sites than any other collagen types
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?
additional information
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type IV collagen contains more prolyl 3-hydroxylation sites than any other collagen types
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?
additional information
?
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the BH4 domain is required for the interaction of PHD3 with Bcl-2, PHD3 promotes apoptosis via its BH4 domain
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additional information
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results identify a role for P3H2 in 3-hydroxylation of non-A1 proline residues in clade A collagen chains
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?