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1.14.11.7: procollagen-proline 3-dioxygenase

This is an abbreviated version!
For detailed information about procollagen-proline 3-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.7

Reaction

[procollagen]-L-proline
+
2-oxoglutarate
+
O2
=
[procollagen]-trans-3-hydroxy-L-proline
+
succinate
+
CO2

Synonyms

LEPRE1, Leprel1, Leprel2, More, oxygenase, protocollagen proline 3-di-, P3H1, P3H2, P3H3, PHD3, proline,2-oxoglutarate 3-dioxygenase, prolyl 3-hydroxylase, prolyl 3-hydroxylase 1, prolyl 3-hydroxylase 2, prolyl 3-hydroxylase-2, prolyl hydroxylase, prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating, protocollagen proline 3-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.7 procollagen-proline 3-dioxygenase

Substrates Products

Substrates Products on EC 1.14.11.7 - procollagen-proline 3-dioxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(Gly-L-Pro-L-4-hydroxyproline)5 + 2-oxoglutarate + O2
(Gly-trans-3-hydroxy-L-Pro-trans-4-hydrox-L-Pro)5 + succinate + CO2
show the reaction diagram
-
-
-
?
(L-Pro-trans-4-hydroxy-L-Pro-Gly)5 + 2-oxoglutarate + O2
(trans-3-hydroxy-L-Pro-trans-4-hydroxy-L-Pro-Gly)5 + succinate + CO2
show the reaction diagram
-
-
-
?
L-Leu-L-Asn-Gly-L-Leu-L-4Hyp-Gly-L-Pro-L-Ile-Gly-L-Pro-L-4Hyp-Gly-L-Pro-L-Arg-Gly-L-Arg-L-Thr-Gly-L-Asp-L-Ala-Gly + 2-oxoglutarate + O2
L-Leu-L-Asn-Gly-L-Leu-L-4Hyp-Gly-trans-3-hydroxy-L-Pro-L-Ile-Gly-L-Pro-L-4Hyp-Gly-trans-3-hydroxy-L-Pro-L-Arg-Gly-L-Arg-L-Thr-Gly-L-Asp-L-Ala-Gly + succinate + CO2
show the reaction diagram
peptide corresponding to the only prolyl 3-hydroxylation site in the alpha1 chain of collagen I
-
-
?
L-Pro-L-Thr-Gly-L-Pro-L-Arg-Gly-L-Phe-L-Pro-Gly-L-Pro-L-4-hydroxyproline-Gly-L-Pro-L-Asp-Gly-L-Leu-L-4-hydroxyproline-Gly-L-Ser-L-Met-Gly + 2-oxoglutarate + O2
? + succinate + CO2
show the reaction diagram
peptide corresponding to a known prolyl 3-hydroxylation site in the alpha1 chain of collagen IV
-
-
?
L-proline + 2-oxoglutarate + O2
trans 3-hydroxy-L-proline + succinate
show the reaction diagram
-
-
-
-
?
L-proline-[collagen] + O2
(S3)-hydroxy-L-proline-[collagen]
show the reaction diagram
prolyl 3-hydroxylase 1 modifies a single proline residue in the alpha chains of type I, II, and III collagens to (3S)-hydroxyproline
-
-
?
L-proline-[collagen] + O2
3-hydroxy-L-proline-[collagen]
show the reaction diagram
-
-
-
?
L-Ser-L-Lys-Gly-L-Glu-L-Gln-Gly-L-Phe-L-Met-Gly-L-Pro-L-4-hydroxyproline-Gly-L-Pro-L-Gln-Gly-L-Gln-L-4-hydroyproline-Gly-L-Leu-L-4-hydroxyproline-Gly + 2-oxoglutarate + O2
? + succinate + CO2
show the reaction diagram
peptide corresponding to a known prolyl 3-hydroxylation site in the alpha1 chain of collagen IV
-
-
?
procollagen + 2-oxoglutarate + O2
procollagen trans-3-hydroxy-L-proline + succinate + CO2
show the reaction diagram
procollagen L-proline + 2-oxoglutarate + O2
procollagen trans-3-hydroxy-L-proline + succinate + CO2
show the reaction diagram
protocollagen containing 4-hydroxyproline + 2-oxoglutarate + O2
?
show the reaction diagram
[procollagen]-L-proline + 2-oxoglutarate + O2
[procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
show the reaction diagram
additional information
?
-