1.14.11.73: [protein]-arginine 3-hydroxylase

This is an abbreviated version!
For detailed information about [protein]-arginine 3-hydroxylase, go to the full flat file.

Reaction

Synonyms

JMJD5, KDM8

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.73 [protein]-arginine 3-hydroxylase

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Results	in table
4	AA Sequence
2	Crystallization (Commentary)
2	General Information
1	Inhibitors
1	Metals/Ions
3	Organism
3	Protein Variants
1	Reaction
3	Reference
4	Substrates and Products (Substrate)
6	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.14.11.73 - [protein]-arginine 3-hydroxylase

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SYSTEMATIC NAME

IUBMB Comments

[protein]-L-arginine,2-oxoglutarate:oxygen oxidoreductase (3R-hydroxylating)

The enzyme, characterized from humans, catalyses the stereoselective formation of the (2S,3R)-hydroxy-L-arginine stereoisomer. So far the enzyme has been shown to act on two substrates - the 40S ribosomal protein S6 (RPS6), which is hydroxylated at R137, and, at a lower activity, RCCD1, a protein involved in chromatin stability, which is hydroxylated at R141. Even though the same stereoisomer is produced by the bacterial EC 1.14.11.47, [50S ribosomal protein L16]-arginine 3-hydroxylase, the two enzymes do not exhibit any cross-reactivity on their respective ribosomal protein substrates.