1.14.11.77: alkyl sulfatase

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For detailed information about alkyl sulfatase, go to the full flat file.

Word Map on EC 1.14.11.77

1.14.11.77

sds

detergent

sulfatases

putida

surfactants

bovis

bioremediation

moreau

intergenic

rrna

Reaction

Synonyms

2-oxoglutarate-dependent sulfate ester dioxygenase, alpha-ketoglutarate-dependent sulfate ester dioxygenase, AtsK, Rv3406, type II alkyl sulfatase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.77 alkyl sulfatase

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Results	in table
1	Activating Compound
2	AA Sequence
3	Cloned(Commentary)
2	Crystallization (Commentary)
3	General Information
1	Inhibitors
8	KM Value [mM]
2	Metals/Ions
4	Organism
1	pH Optimum
1	Purification (Commentary)
1	Reaction
4	Reference
18	Substrates and Products (Substrate)
1	Subunits
12	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.14.11.77 - alkyl sulfatase

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primary alkyl sulfate ester, 2-oxoglutarate:oxygen oxidoreductase (sulfate-hydrolyzing)

Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors. The type II sulfatases oxidize the C-H bond of the carbon next to the sulfate ester, using 2-oxoglutarate and oxygen as substrates. The resulting hemiacetal sulfate ester collapses, liberating inorganic sulfate and an alkyl aldehyde along with carbon dioxide and succinate. The enzymes often desulfate a broad spectrum of linear and branched-chain sulfate esters. The enzyme from Pseudomonas putida acts on a range of medium-chain alkyl sulfate esters, with chain lengths ranging from C(4) to C(12). cf. sulfatase EC 3.1.6.1, arylsulfatase (type I), EC 3.1.6.21, linear primary-alkylsulfatase, and EC 3.1.6.22, branched primary-alkylsulfatase.