1.14.11.8: trimethyllysine dioxygenase

This is an abbreviated version!
For detailed information about trimethyllysine dioxygenase, go to the full flat file.

Reaction

Synonyms

6-N-trimethyllysine dioxygenase, epsilon-N-trimethyllysine hydroxylase, epsilon-trimethyllysine 2-oxoglutarate dioxygenase, eta-N-trimethyllysine hydroxylase, Nepsilon-trimethyllysine hydroxylase, oxygenase, trimethyllysine di-, TML dioxygenase, TML hydroxylase, TML-alpha-ketoglutarate dioxygenase, TMLD, TMLH, TMLH-a, TMLH-b, trimethyllysine alpha-ketoglutarate dioxygenase, trimethyllysine hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.8 trimethyllysine dioxygenase

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Results	in table
9	Activating Compound
1739	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
6	Cofactor
1	Expression
14	General Information
14	Inhibitors
18	KM Value [mM]
13	Localization
17	Metals/Ions
5	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
22	Organism
5	Pathway
7	pH Optimum
1	Posttranslational Modification
8	Protein Variants
5	Purification (Commentary)
1	Reaction
1	Reaction Type
22	Reference
32	Source Tissue
2	Specific Activity [micromol/min/mg]
2	Storage Stability
34	Substrates and Products (Substrate)
3	Subunits
42	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 1.14.11.8 - trimethyllysine dioxygenase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2

(3S)-3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2

4 entries

N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2

3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2

4 entries

additional information

?

-

Rattus norvegicus

-

enzyme is localized to the mitochondrial matrix, product formation is limited by 6-N-trimethyllysine transport across the mitochondrial inner membrane

686678

-

-

?

N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2

(3S)-3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2

Homo sapiens

Q9NVH6

-

744678, 744681, 745958, 745961

-

-

?

N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2

(3S)-3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2

Homo sapiens

-

-

745961

-

-

?

N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2

(3S)-3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2

Homo sapiens

Q9NVH6

-

746366, 764104

-

-

?

N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2

(3S)-3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2

Homo sapiens

-

-

764104

-

-

?

N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2

3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2

Mus musculus

Q91ZE0

-

691166

-

-

?

N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2

3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2

Rattus norvegicus

-

carnitine biosynthesis

7019

-

-

?

N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2

3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2

Rattus norvegicus

Q91ZW6

first enzyme of the L-carnitine biosynthesis

652164

-

652164

?

N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2

3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2

Sus scrofa

-

-

697027

-

-

?