1.14.11.B19: [histone H3]-trimethyl-L-lysine56 demethylase

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For detailed information about [histone H3]-trimethyl-L-lysine56 demethylase, go to the full flat file.

Reaction

Synonyms

JMJD2D, KDM4DL, KDM4E, lysine-specific demethylase 4E

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.B19 [histone H3]-trimethyl-L-lysine56 demethylase

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Reaction

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Reaction on EC 1.14.11.B19 - [histone H3]-trimethyl-L-lysine56 demethylase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

a [histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2

(1a)

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a [histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 3 2-oxoglutarate + 3 O2 = a [histone H3]-L-lysine56 + 3 succinate + 3 formaldehyde + 3 CO2

overall reaction

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a [histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2

(1b)

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