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1.14.12.12: naphthalene 1,2-dioxygenase

This is an abbreviated version!
For detailed information about naphthalene 1,2-dioxygenase, go to the full flat file.

Word Map on EC 1.14.12.12

Reaction

Naphthalene
+
NADH
+
H+
+
O2
=
(1R,2S)-1,2-dihydronaphthalene-1,2-diol
+
NAD+

Synonyms

NAG, NAHA, nahAc, naphthalene 1,2-dioxygenase, naphthalene dioxygenase, naphthalene oxygenase, NDO, oxygenase, naphthalene di-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
                1.14.12.12 naphthalene 1,2-dioxygenase

General Information

General Information on EC 1.14.12.12 - naphthalene 1,2-dioxygenase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
-
the naphthalene dioxygenase system can develop the capacity of plants to tolerate a high concentration of phenanthrene and metabolize phenanthrene in vivo
physiological function
electron transfer subunit TmoF stimulates T4MO activity two- to threefold when coexpressed in Escherichia coli or Pseudomonas putida. The reductase component of the naphthalene dioxygenase system, encoded by the nahA gene of plasmid NAH7 from Pseudomonas putida G7, can largely replace the TmoF protein in stimulating T4MO activity, and TmoF can partially replace the NahA protein in forming active naphthalene dioxygenase