1.14.12.13: 2-halobenzoate 1,2-dioxygenase

This is an abbreviated version!
For detailed information about 2-halobenzoate 1,2-dioxygenase, go to the full flat file.

Word Map on EC 1.14.12.13

Reaction

a 2-halobenzoate +

NADH
+
H+
+
O2
=
catechol
+ a halide anion +
NAD+
+
CO2

Synonyms

(chloro)benzoate dioxygenase, 2-chlorobenzoate 1,2-dioxygenase, 2-halobenzoate 1,2-dioxygenase, 2-halobenzoate dioxygenase, 2-halobenzoate dioxygenase system, BenA, CbdAB, cbdABC

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
                1.14.12.13 2-halobenzoate 1,2-dioxygenase

Inhibitors

Inhibitors on EC 1.14.12.13 - 2-halobenzoate 1,2-dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,2'-dipyridyl
-
100% inhibition at 1 mM
Cu2+
-
100% inhibition compared to the activity without any metal
FAD
-
slight inhibition
Fe2+
-
slight inhibition
iodoacetate
-
55% inhibition at 2 mM
KCN
-
40% inhibition at 2 mM
N-ethylmaleimide
-
100% inhibition at 2 mM
Ni2+
-
25% inhibition compared to the activity without any metal
o-phenanthroline
-
100% inhibition at 0.5 mM
p-chloromercuribenzoate
-
17% inhibition at 0.005 mM
Zn2+
-
40% inhibition compared to the activity without any metal
additional information
-
no inhibition with sodium azide
-