1.14.12.16: 2-Hydroxyquinoline 5,6-dioxygenase

This is an abbreviated version!
For detailed information about 2-Hydroxyquinoline 5,6-dioxygenase, go to the full flat file.

Reaction

quinolin-2-ol
+
NADH
+
H+
+
O2
=
2,5,6-trihydroxy-5,6-dihydroquinoline
+
NAD+

Synonyms

2-Hydroxyquinoline 5,6-dioxygenase, 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase, Oxygenase, 2(1H)-quinolinone 5,6-di-, Quinolin-2(1H)-one 5,6-dioxygenase, Quinolin-2-ol 5,6-dioxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
                1.14.12.16 2-Hydroxyquinoline 5,6-dioxygenase

Inhibitors

Inhibitors on EC 1.14.12.16 - 2-Hydroxyquinoline 5,6-dioxygenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
0.5 mM, 82% loss of activity
4-hydroxymercuribenzoate
-
0.1 mM, complete loss of activity
Acriflavin
-
0.5 mM, 69% loss of activity
diethyldithiocarbaminate
-
inhibits after a prolonged incubation time
EDTA
-
inhibits after a prolonged incubation time
iodoacetate
-
2 mM, complete loss of activity
NaCl
-
0.2 M, 50% loss of activity
Quinacrine
-
0.5 mM, 15% loss of activity